The primary treatment method for Mycoplasma pneumoniae is the use of antimicrobial drugs targeting Mycoplasma pneumoniae. As Mycoplasma is quite unique, being neither bacteria nor virus but a small microorganism that lies between the two, many antibiotics are ineffective against it. Therefore, the choice of antimicrobial drugs is very important in treating Mycoplasma pneumoniae. Currently, the most commonly used are three major classes, the first being macrolides, such as erythromycin, roxithromycin, azithromycin, etc. However, the resistance rate of Mycoplasma to macrolide drugs is relatively high, reaching over forty percent in some regions. Another commonly used class is fluoroquinolones, such as levofloxacin and moxifloxacin, but these drugs can only be used in adults over eighteen years of age. Another option is the tetracycline class, with commonly used drugs including doxycycline. Besides antimicrobial treatment, patients with Mycoplasma pneumoniae often experience severe coughing and phlegm; at this time, we may selectively use some antitussive drugs. Specific drug treatments should be conducted under the guidance of a doctor.