Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by symmetrical polyarthritis. It belongs to auto-immune diseases and is not an infectious disease; the cause of which is currently unclear. There is also considerable individual variation in its clinical manifestations. Because it is an autoimmune disease, it cannot be cured. This relates to whether or not one can donate blood: firstly, blood donors must not have any infectious diseases. Secondly, since this disease cannot be cured and patients often need to take regular doses of medications such as methotrexate, leflunomide, and sulfasalazine, there will be a certain concentration of these drugs in the body. If the condition allows and there are no infectious diseases, blood donation may be appropriately considered.