Hand, foot, and mouth disease is a contagious viral infection primarily characterized by scattered vesicular or papular rashes on the hands, feet, mouth, and buttocks. It is generally a mild condition, and typical symptoms include fever and rash. It can be treated with oral medications and by taking care of oral and skin hygiene, usually healing quickly. Severe cases caused by the EV71 virus can lead to varying degrees of intracranial pressure. In such serious cases, prompt treatment with mannitol and furosemide to reduce intracranial pressure is necessary; corticosteroids may also be needed if required. For children with severe hypoxia, timely correction of oxygen deficiency is crucial, along with intravenous fluids to maintain stable blood pressure, respiration, heart rate, and microcirculation. (Please consult a professional physician for medication guidance and do not self-medicate.)