Hand, foot, and mouth disease is a contagious childhood exanthem caused by an intestinal virus infection. The primary symptoms of most hand, foot, and mouth diseases include fever, followed by rashes on the hands, feet, mouth, and buttocks, as well as vesicles in the throat. However, not all children with the disease necessarily experience continuous fever or any fever at all. Some only show symptoms after coming into contact with an infected person, with rashes on the hands, feet, mouth, and buttocks, and vesicles in the throat. In such cases, it is still considered hand, foot, and mouth disease, and fever is not a requisite for diagnosis. Thus, the presence of fever should not be solely relied upon for diagnosing the disease.