Hand, foot, and mouth disease is a contagious disease caused by an infection of enteroviruses. There are more than 20 types of enteroviruses that cause the disease, with Coxsackievirus A16 and Enterovirus 71 being the most common. The main clinical manifestations of this disease include blisters on the hands, feet, mouth, and buttocks. Some patients may experience fever, while others may have no fever or only a mild fever. The disease is contagious and primarily transmitted through contact. For example, it can be spread through saliva, droplets, hand-to-mouth contact, and contact with the secretions from the blisters, among other methods.