Upper gastrointestinal bleeding presenting as hematemesis indicates a bleeding volume of at least 200 mL. If a patient experiences upper gastrointestinal bleeding accompanied by vomiting blood, it suggests a significant amount of bleeding and should be taken very seriously. Patients should seek treatment at a specialized gastrointestinal department of a reputable hospital and have an endoscopic examination as soon as possible to confirm the diagnosis. In addition, endoscopic hemostasis can be performed. After the occurrence of hematemesis due to upper gastrointestinal bleeding, it is recommended to be hospitalized for treatment. Treatment should also include the use of hemostatic drugs, acid-suppressing medications, and drugs that protect the gastric mucosa. Acid suppression medications can include proton pump inhibitors or H2 receptor antagonists, among others.