What are the symptoms of ovarian cancer?

Written by Liu Liang
Oncology
Updated on March 08, 2025
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Some early symptoms of ovarian cancer patients include a lump in the abdomen that can be felt during gynecological examination or by the patients themselves. In advanced ovarian cancer, as the tumor progressively enlarges, there may be symptoms like abdominal pain, bloating, decreased appetite, and weight loss. Moreover, the tumor may compress other organs in the pelvic cavity, causing symptoms such as a feeling of heaviness in the lower abdomen or even constipation. Additionally, many patients with ovarian cancer may develop significant ascites, which can also cause abdominal distension, decreased appetite, and even nausea and vomiting, along with other gastrointestinal symptoms.

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Written by Liu Liang
Oncology
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How long can one live with ovarian cancer?

The lifespan of ovarian cancer patients depends on several factors including the specific stage of the cancer, the patient's sensitivity and response to treatment, and the overall health of the patient, leading to significant individual variability. The cancer is typically classified into stages from one to four, with stage one being the earliest and stage four being the most advanced. Generally, patients diagnosed at an earlier stage tend to have a better prognosis and a greater chance of survival compared to those with advanced ovarian cancer. Additionally, patients in advanced stages who respond well to treatments like chemotherapy typically have a better prognosis and longer survival times compared to those who are less responsive to such treatments. Hence, it is impossible to generalize as the individual differences are substantial.

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Written by Liu Liang
Oncology
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Ovarian Cancer Screening Methods

The methods for diagnosing ovarian cancer include imaging studies, such as ultrasonography of the adnexa of the uterus, abdominal CT, or MRI, which can detect ovarian tumors. The next step is to perform a blood test for the tumor marker CA125, which is a relatively specific and sensitive marker for epithelial ovarian cancer; in clinical practice, CA125 levels are generally significantly elevated in patients with ovarian cancer. Additionally, many patients with ovarian cancer, especially those in advanced stages, often develop significant ascites. We can perform abdominal paracentesis to drain the fluid and test the ascites for cancer cells. If cancer cells are found in the ascites and imaging studies reveal an ovarian mass, ovarian cancer can be diagnosed. Furthermore, chest CT and other tests are included to comprehensively assess the staging of the patient.

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Written by Liu Liang
Oncology
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ovarian cancer specific drug

Ovarian cancer does not have any specific cure-all treatment. Most ovarian cancers are epithelial ovarian cancers, and there is also ovarian cancer resulting from malignant germ cells, which is a rarer pathology type. For epithelial ovarian cancer, treatment methods include surgery, radiation therapy, chemotherapy, and some targeted therapies, mainly using Bevacizumab, which is a monoclonal antibody that inhibits angiogenesis, and is usually used in combination with chemotherapy drugs. For patients with advanced ovarian cancer, those who are resistant to chemotherapy, or those in poor general health unable to endure chemotherapy, palliative treatments like hormone treatment using progestogens are an option, along with immune therapy being available nowadays. Surgery is primarily for early-stage ovarian cancer patients, where curative surgical resection is possible, or for debulking surgery in patients with advanced ovarian cancer. Chemotherapy is frequently used as it is relatively effective for epithelial ovarian cancer, a type of cancer that is somewhat sensitive to such treatments. The drugs used mainly include taxane combined with platinum-based chemotherapy. For intravenous administration or intraperitoneal delivery—for the latter, mainly for ovarian cancers complicated by extensive ascites—, positioning an abdominal drainage tube and then infusing platinum-based chemotherapy drugs into the abdominal cavity are utilized.

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Written by Liu Liang
Oncology
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Early Symptoms of Ovarian Cancer

Patients with ovarian cancer may have relatively hidden clinical symptoms in the early stages, possibly without any specific discomfort, or just mild lower abdominal bloating or pain. Symptoms tend to become more apparent only when the tumor progressively enlarges or when ascites occur, such as increased abdominal bloating and pain. Furthermore, during a physical examination, a solid or cystic-solid mass can be palpated in the pelvic area. Ascites can also lead to clinical symptoms such as nausea and vomiting. In the late stages, partial intestinal obstruction or symptoms related to pelvic compression may appear.

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Written by Zhou Chen
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How is ovarian cancer diagnosed?

Early screening for ovarian cancer allows for about 20% of cases to be diagnosed in their early stages. Detection generally follows these procedures: 1. Routine gynecological health check-ups. 2. Visiting a hospital due to certain symptoms. 3. Ovarian cancer screening. Common methods include transvaginal ultrasound and serum CA125 testing. Additional tests include tumor marker CA125 and checks for AFP, CA19-9, and CEA. Ultrasonography (B-ultrasound) can preliminarily determine the tumor size, shape, solidity, location, and its relation to surrounding organs. CT scans and MRI can further clarify the tumor's nature and the extent of invasion into the abdominal and pelvic organs. If necessary, gastroscopy can be performed to rule out primary gastrointestinal tumors, and if economic conditions allow, a PADCT scan can also be conducted.