Early Symptoms of Ovarian Cancer

Written by Liu Liang
Oncology
Updated on September 22, 2024
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Patients with ovarian cancer may have relatively hidden clinical symptoms in the early stages, possibly without any specific discomfort, or just mild lower abdominal bloating or pain. Symptoms tend to become more apparent only when the tumor progressively enlarges or when ascites occur, such as increased abdominal bloating and pain. Furthermore, during a physical examination, a solid or cystic-solid mass can be palpated in the pelvic area. Ascites can also lead to clinical symptoms such as nausea and vomiting. In the late stages, partial intestinal obstruction or symptoms related to pelvic compression may appear.

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Oncology
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ovarian cancer specific drug

Ovarian cancer does not have any specific cure-all treatment. Most ovarian cancers are epithelial ovarian cancers, and there is also ovarian cancer resulting from malignant germ cells, which is a rarer pathology type. For epithelial ovarian cancer, treatment methods include surgery, radiation therapy, chemotherapy, and some targeted therapies, mainly using Bevacizumab, which is a monoclonal antibody that inhibits angiogenesis, and is usually used in combination with chemotherapy drugs. For patients with advanced ovarian cancer, those who are resistant to chemotherapy, or those in poor general health unable to endure chemotherapy, palliative treatments like hormone treatment using progestogens are an option, along with immune therapy being available nowadays. Surgery is primarily for early-stage ovarian cancer patients, where curative surgical resection is possible, or for debulking surgery in patients with advanced ovarian cancer. Chemotherapy is frequently used as it is relatively effective for epithelial ovarian cancer, a type of cancer that is somewhat sensitive to such treatments. The drugs used mainly include taxane combined with platinum-based chemotherapy. For intravenous administration or intraperitoneal delivery—for the latter, mainly for ovarian cancers complicated by extensive ascites—, positioning an abdominal drainage tube and then infusing platinum-based chemotherapy drugs into the abdominal cavity are utilized.

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Ovarian cancer pain symptoms

In the early stages of ovarian cancer, the symptoms can be quite hidden, and the patient may not feel any discomfort at all. However, as the tumor grows and ascites develops, the patient typically may experience abdominal bloating, or a palpable mass may be felt in the pelvic or lower abdominal area. At this point, symptoms such as pain in the lower abdomen may occur, especially when there is a substantial amount of ascites, leading to clinical symptoms like abdominal bloating and pain. In even more advanced stages of ovarian cancer, the tumor may invade surrounding pelvic organs, potentially causing partial intestinal obstruction or symptoms of pelvic compression. With conditions like intestinal obstruction, there will be significant abdominal pain, possibly accompanied by vomiting, especially after eating, which can exacerbate the symptoms.

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early symptoms of ovarian cancer

The early symptoms of ovarian cancer in patients are often not very obvious, so they are not easily noticed. The more common symptom is an abdominal mass, meaning you can feel a lump in the abdomen. In its early stages, the abdominal mass is not large and is not easily detectable. Most patients only discover it during gynecological examinations. As the disease progresses, the mass grows larger and the abdomen visibly expands, leading to symptoms like abdominal pain, bloating, or lower abdominal discomfort. Another symptom is ascites, which is a more common sign in patients with advanced ovarian cancer.

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Oncology
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Can ovarian cancer be cured?

Whether ovarian cancer can be cured depends on the clinical stage of the patient, as well as the patient's sensitivity to treatment, among other factors. If it is a case of early-stage ovarian cancer, curative surgery can be performed. After surgery, based on the pathology, it can be decided whether postoperative adjuvant radiotherapy or chemotherapy is necessary. Patients with early-stage ovarian cancer who undergo surgery or postoperative adjuvant radiotherapy and chemotherapy may have hope for a cure. However, if the cancer is discovered at a late stage where it has spread extensively, such as widespread metastasis to the pelvic area, or even to distant organs like the lungs or liver, then the treatment for these patients is primarily chemotherapy. A cure is not achievable; the treatment aims to alleviate symptoms and prolong the patient's life. Thus, for patients with late-stage ovarian cancer, treatment cannot achieve a curative purpose.

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How is ovarian cancer diagnosed?

Ovarian cancer is discovered through transvaginal ultrasound of the adnexa uteri revealing ovarian tumors, or through imaging studies such as abdominal CT scans or MRIs showing ovarian tumors, combined with tumor markers, particularly the ovarian epithelial cancer tumor marker CA125, which will be significantly elevated. Generally, with these findings, ovarian cancer can typically be clinically diagnosed. Confirmation, however, requires pathological diagnosis, which involves obtaining a biopsy of the tumor. This can be done through a puncture biopsy or through pathological examination after surgical excision to confirm ovarian cancer. Additionally, some patients with ovarian cancer present with substantial ascites at the time of discovery. If cancer cells are found in the abdominal fluid, combined with a significant increase in CA125 and imaging studies showing ovarian tumors, ovarian cancer can also be diagnosed.