Clinical manifestations of renal cancer

Written by Li Yuan Wei
Urology
Updated on February 25, 2025
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The clinical manifestations and staging of kidney cancer are related to the most common early-stage kidney cancer, late-stage kidney cancer, or metastatic kidney cancer. Generally, early-stage kidney cancer exhibits few clinical symptoms and is often detected during physical examinations, through ultrasonography of the urinary tract, or kidney ultrasonography, where tumors are the most commonly found. Additionally, later stages of kidney cancer often present as swelling pain in the waist area or occasional hematuria. More serious conditions involve feeling a mass in the upper abdomen upon palpation, which is a clinical manifestation. Nowadays, with heightened awareness for health checks, such conditions are generally discovered through these examinations. When major clinical manifestations like hematuria and abdominal masses occur, it indicates that the kidney tumor has already progressed to the mid or late stages.

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Survival rate after early removal of kidney cancer

The prognosis of renal cancer is closely related to its clinical staging. If it is in the early stages, surgery is the preferred treatment and the prognosis is very good. Timely surgery followed by subsequent treatments such as immunotherapy, targeted therapy, etc., is recommended. For early-stage renal cancer, the five-year survival rate after surgical removal can exceed 90%, and some patients may live without issues for over 20 years. How long someone lives specifically also depends on the individual's constitution and physical condition.

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How many centimeters is kidney cancer in the early stage?

Generally speaking, kidney cancers smaller than 4 centimeters are usually considered early stage, but it still depends on individual circumstances, such as whether the tumor has spread or metastasized, and the malignancy level of the tumor cells. Thus, assessing whether it is early or advanced stage requires consideration of these specific factors, and it cannot be simply determined by size alone.

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Is kidney cancer prone to metastasis?

Kidney cancer in its early stages generally does not metastasize. If it does metastasize, it usually follows several paths: one is hematogenous or lymphatic spread, followed by local diffusion, and then the tumor invades surrounding fat or blood vessels, which is local diffusion. It is also important to note that there is a pseudo-capsule around the kidney cancer that prevents the spread of cancer cells. Metastasis is not likely when the tumor is small, but as the tumor size increases or in some special types of tumor cells, metastasis may occur.

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How long can someone with kidney cancer and hematuria survive?

A common symptom of kidney cancer is painless visible blood in urine, which is also the primary initial symptom. It is intermittent and sometimes accompanied by blood clots. However, after exhibiting this symptom, how long a patient can live depends on individual constitution and the severity of the condition. Once discovered, early surgical treatment is recommended, followed by immunotherapy, such as using interferons and interleukins.

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What tests are done to diagnose kidney cancer?

The typical clinical manifestations of renal cancer are hematuria, a mass, and flank pain, but these symptoms generally appear only in the middle and late stages. CT scans often play a decisive role in the diagnosis of renal cancer. Ultrasound examinations are mainly used to screen for the presence of tumors in the entire urinary system, while excretory urography can reveal compression inside the renal pelvis by the tumor, which may show irregular deformations, narrowing, or elongation. Generally speaking, CT scans are quite important for the diagnosis of renal cancer and also play a decisive role.