Can tertiary syphilis be transmitted?

Written by Zhu Zhu

Dermatology

Updated on April 14, 2025

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Third-stage syphilis is contagious, but its infectivity is weaker compared to first-stage and second-stage syphilis. However, the damage caused by third-stage syphilis is very severe, often causing damage to tissues and organ functions. It can potentially cause disabilities, deformities, or even life-threatening conditions. Therefore, the characteristic of third-stage syphilis is its weak infectivity but strong damaging effects. Thus, it is crucial to take third-stage syphilis seriously and seek regular and timely treatment.

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Written by Qu Jing

Dermatology

1min 58sec

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How long is the latency period of syphilis?

Syphilis is a chronic infectious disease caused by the bacterium Treponema pallidum (TP), primarily transmitted through sexual contact and blood. The impact of syphilis is significant as it can affect all bodily tissues and organs, or can be transmitted through the placenta, leading to stillbirth, miscarriage, premature birth, and congenital infections. When syphilis is suspected, due to its complex clinical manifestations, a detailed medical history should be taken, a thorough physical examination conducted, and repeated laboratory tests performed to ensure an early and accurate diagnosis. It is important to trace back to any unprotected sexual contacts within the last six weeks and to routinely screen the sexual partners of patients for syphilis as well. Syphilis is divided into three stages: The diagnosis of primary syphilis is mainly based on the history of exposure, the incubation period (six weeks), typical clinical manifestations, and laboratory tests, noting that a negative syphilis serology result alone should not exclude the diagnosis of syphilis. The diagnosis of secondary syphilis primarily relies on the history of exposure, typical clinical manifestations, especially skin and mucosal lesions, combined with laboratory tests. The diagnosis of tertiary syphilis is mainly based on the history of exposure, typical clinical manifestations, and laboratory tests. Neurosyphilis can also be assessed through cerebrospinal fluid examination. Congenital syphilis primarily requires a maternal history of the disease, combined with typical clinical manifestations and laboratory tests for diagnosis.

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Written by Zhu Zhu

Dermatology

39sec

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Can third-stage syphilis still be cured?

Third-stage syphilis can still possibly be cured, but this varies from person to person and is not absolute. Usually, when syphilis develops to the third stage, it indicates a more severe infection and is considered late-stage. Additionally, third-stage syphilis is particularly prone to causing cardiovascular, neurological, and musculoskeletal damages, which are complications. Therefore, treating third-stage syphilis is much more challenging compared to the first and second stages. It is crucial to treat and diagnose it early.

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Written by Zhai Yu Juan

Dermatology Department

38sec

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Is syphilis contagious?

Syphilis is a sexually transmitted disease caused by infection with the syphilis spirochete. After infection, the pathogen can invade various organs throughout the body, causing a variety of symptoms. As a classic sexually transmitted disease, syphilis is contagious, with its main routes of transmission being through sexual contact, mother-to-child transmission, and also through close contact, such as kissing, or the use of daily items from a syphilis patient, such as towels, razors, cutlery, etc. If syphilis is not treated, its infectivity gradually decreases over time.

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Written by Li Chang Yue

General Surgery

1min 4sec

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Is cervical lymphadenopathy related to syphilis?

Enlargement of cervical lymph nodes is somewhat related to syphilis. Although cervical lymph node enlargement is not necessarily solely caused by syphilis, if syphilis progresses to its secondary or tertiary stages, it tends to cause lymph node enlargement, and severe cases may even lead to ulceration. This happens because after a syphilis infection, immune responses in the lymph cells are triggered by the Treponema pallidum, leading to the enlargement of cervical lymph nodes, and also possibly the lymph nodes under the arms and in the groin area. In such cases, it is advised to seek timely medical attention, complete the necessary immunological testing, and ensure an accurate diagnosis of syphilis. If cervical lymph node enlargement occurs, prolonged treatment with penicillin should be administered, as it effectively controls the Treponema pallidum and can help reduce the severity of the lymph node enlargement.

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Written by Zhu Zhu

Dermatology

43sec

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When is the third stage of syphilis?

Tertiary syphilis is a relatively late stage of syphilis, often occurring two to three years after the initial detection of the disease. For patients with a longer course of the disease, it generally appears five to ten years later. Once tertiary syphilis is diagnosed, it is often accompanied by damage to various organ functions, such as the cardiovascular system, bones, skin, and nervous system. Therefore, it is crucial to detect and treat syphilis early and to follow standard treatment protocols with a doctor. Otherwise, once it progresses to tertiary syphilis, it becomes very difficult to cure.