Enlargement of cervical lymph nodes is somewhat related to syphilis. Although cervical lymph node enlargement is not necessarily solely caused by syphilis, if syphilis progresses to its secondary or tertiary stages, it tends to cause lymph node enlargement, and severe cases may even lead to ulceration. This happens because after a syphilis infection, immune responses in the lymph cells are triggered by the Treponema pallidum, leading to the enlargement of cervical lymph nodes, and also possibly the lymph nodes under the arms and in the groin area. In such cases, it is advised to seek timely medical attention, complete the necessary immunological testing, and ensure an accurate diagnosis of syphilis. If cervical lymph node enlargement occurs, prolonged treatment with penicillin should be administered, as it effectively controls the Treponema pallidum and can help reduce the severity of the lymph node enlargement.