What are the early symptoms of syphilis?

Written by Zhang Jian Bo
Dermatology
Updated on January 12, 2025
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Syphilis is divided into overt and latent syphilis. Latent syphilis, regardless of whether it is early or late stage, shows no symptoms at all and can only be confirmed by blood testing. The symptoms in the early stage are mainly those of overt syphilis, primarily manifestations of primary syphilis. The stages of primary, secondary, and tertiary syphilis begin with the appearance of a lesion at the site of infection, typically about 0.5 to 1 centimeter in diameter, with a hard, dark red nodule that feels like cartilage. The surface may have ulcers; it may be painless, or there may be no pain at all. Subsequently, nearby lymph nodes may become enlarged. This swelling of the lymph nodes is characterized by being painless, usually unilateral, with no redness or rupture. These are the clear symptoms of overt primary syphilis. If treated properly at this stage, recovery is generally rapid.

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Written by Zhu Zhu
Dermatology
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Can tertiary syphilis be contagious?

Third-stage syphilis is contagious. Although the titers in third-stage syphilis might be lower than those in the first and second stages, it still has the ability to infect others. Moreover, third-stage syphilis can easily lead to many complications, affecting other tissues and organs of the body. Therefore, third-stage syphilis is very serious. Once third-stage syphilis occurs, one must be particularly vigilant, seek timely treatment in a reputable hospital early, enhance their immunity, and avoid having a history of unprotected sexual activity.

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Written by Zhu Zhu
Dermatology
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Can tertiary syphilis be treated?

Third-stage syphilis is treatable, but typically, it develops two to three years after the initial syphilis infection, making it more severe than both the first and second stages—this is what we refer to as late-stage syphilis. Therefore, treating third-stage syphilis is somewhat more challenging than treating the first and second stages. Additionally, third-stage syphilis particularly tends to cause damage to cardiovascular, neurological, joint, and other organ systems. If it leads to severe complications, it can easily result in deformities, disabilities, or even death. Therefore, it is crucial to be especially vigilant if diagnosed with third-stage syphilis and to seek timely treatment at a hospital.

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Written by Zhu Zhu
Dermatology
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Is third-stage syphilis contagious?

Third-stage syphilis is infectious, but its contagiousness is relatively weak compared to first-stage and second-stage syphilis. The titers detected in third-stage syphilis are usually lower, so its infectiousness is comparatively minor. However, third-stage syphilis still has the capability to infect others. Therefore, patients with third-stage syphilis must actively seek treatment and refrain from having sexual relations with others, while also enhancing their own immunity.

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Written by Zhu Zhu
Dermatology
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Can you still have children with third-stage syphilis?

Third-stage syphilis is the most severe stage of the disease, and it is not possible to have children if one has third-stage syphilis, because syphilis can be transmitted from mother to fetus. The infectivity is particularly strong during the third stage. If a child is conceived at this time, it could lead to stillbirth. Besides stillbirth, even if the child is born by chance, they may have abnormal development or be born with diseases. This is tremendously painful and tormenting for both the parent and child. Therefore, one cannot have children with third-stage syphilis.

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Written by Zhu Zhu
Dermatology
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Early symptoms of syphilis

Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum, with the disease course within two years referred to as early syphilis. Not all infected individuals display symptoms; asymptomatic syphilis is also known as latent syphilis. Symptomatic early syphilis primarily manifests as either primary or secondary syphilis. The main symptom of primary syphilis is a chancre, typically occurring as a clear-bordered ulcer in the genital area. It is flesh-colored and neither painful nor itchy. Several weeks after the chancre heals, secondary syphilis can develop, characterized by a rash that may resemble other skin conditions. Common manifestations include macules, papular macules, copper-red papules on hands and feet, flat condyloma, and syphilitic alopecia. Individuals who suspect they may have been exposed to syphilis should visit a hospital for a blood test to detect syphilis antibodies. Antibodies can usually be detected four weeks after infection, and a negative result three months later can rule out syphilis.