What are the early symptoms of syphilis?

Written by Zhang Jian Bo
Dermatology
Updated on January 12, 2025
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Syphilis is divided into overt and latent syphilis. Latent syphilis, regardless of whether it is early or late stage, shows no symptoms at all and can only be confirmed by blood testing. The symptoms in the early stage are mainly those of overt syphilis, primarily manifestations of primary syphilis. The stages of primary, secondary, and tertiary syphilis begin with the appearance of a lesion at the site of infection, typically about 0.5 to 1 centimeter in diameter, with a hard, dark red nodule that feels like cartilage. The surface may have ulcers; it may be painless, or there may be no pain at all. Subsequently, nearby lymph nodes may become enlarged. This swelling of the lymph nodes is characterized by being painless, usually unilateral, with no redness or rupture. These are the clear symptoms of overt primary syphilis. If treated properly at this stage, recovery is generally rapid.

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Written by Huang Ling Juan
Dermatology
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What are the symptoms of syphilitic disease?

The symptoms of syphilitic disease are diverse, and syphilis is divided into early syphilis and late syphilis. In the early stages of syphilis, during the primary phase, it usually presents as a hard chancre on the genital area, without obvious pain. In secondary syphilis, it manifests as polymorphic roseola, usually appearing as patches of varying sizes on the trunk, covered with scales, with no significant itching. In tertiary or late syphilis, there can be damage to multiple systems including bones and nerves. Once syphilis is diagnosed, it is essential to treat it early. Early treatment generally leads to good outcomes, with most people recovering. If it progresses to late stages, treatment outcomes are relatively poor. The first choice of treatment for syphilis is long-acting penicillin.

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Written by Cui Lin Jing
Dermatology
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What are the symptoms of tertiary syphilis?

Tertiary syphilis mainly occurs two to three years, or even five to ten years or longer, after infection. The primary skin manifestations are gummas, which often occur on the extensor side of the lower legs, and can present as ulcerations, erosions, nodules, and hyperplasia. It may also involve bones, joints, the heart, and blood vessels. The main manifestations include aortitis, aortic valve insufficiency, and aortic aneurysms. When the nervous system is involved, it can present as spinal tuberculosis and general paralysis, which are symptoms of paralytic dementia. The diagnosis of tertiary syphilis requires serological tests and cerebrospinal fluid analysis. The treatment involves primarily penicillin and benzathine penicillin, with erythromycin or tetracycline as alternatives for patients allergic to penicillin, and requires a longer course of treatment.

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Written by Zhu Zhu
Dermatology
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Early symptoms of syphilis

Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum, with the disease course within two years referred to as early syphilis. Not all infected individuals display symptoms; asymptomatic syphilis is also known as latent syphilis. Symptomatic early syphilis primarily manifests as either primary or secondary syphilis. The main symptom of primary syphilis is a chancre, typically occurring as a clear-bordered ulcer in the genital area. It is flesh-colored and neither painful nor itchy. Several weeks after the chancre heals, secondary syphilis can develop, characterized by a rash that may resemble other skin conditions. Common manifestations include macules, papular macules, copper-red papules on hands and feet, flat condyloma, and syphilitic alopecia. Individuals who suspect they may have been exposed to syphilis should visit a hospital for a blood test to detect syphilis antibodies. Antibodies can usually be detected four weeks after infection, and a negative result three months later can rule out syphilis.

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Written by Zhu Zhu
Dermatology
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Will third-stage syphilis be asymptomatic?

In the case of third-stage syphilis, it is generally not asymptomatic, as it is already a late stage of the disease that invades multiple systems, such as the musculoskeletal system, nervous system, and even the cardiovascular system. When these systems are invaded, they become damaged, leading to various complications. Therefore, third-stage syphilis typically presents with various signs of organ dysfunction, and it is unlikely to be without any symptoms once it has progressed to this stage.

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Written by Huang Ling Juan
Dermatology
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What are the early symptoms of syphilis in men?

Early symptoms of syphilis in men may include small papules, with the characteristic lesion of early syphilis being a chancre. From the infection with the syphilis spirochete to the appearance of skin symptoms, it usually takes about three weeks on average. The syphilis chancre in men is typically found on the genitals, though a minority may appear in the mouth. The earliest form of a chancre is a solitary papule, which gradually develops into a round or oval-shaped ulcer. The ulcer has clear boundaries, slightly raised edges, and a clean base, feeling firm like cartilage to the touch, without significant pain. When a chancre appears, if a secondary bacterial infection occurs, pain may arise. Men infected with syphilis must seek early treatment as early-stage syphilis can be completely cured.