Third-stage syphilis can still possibly be cured, but this varies from person to person and is not absolute. Usually, when syphilis develops to the third stage, it indicates a more severe infection and is considered late-stage. Additionally, third-stage syphilis is particularly prone to causing cardiovascular, neurological, and musculoskeletal damages, which are complications. Therefore, treating third-stage syphilis is much more challenging compared to the first and second stages. It is crucial to treat and diagnose it early.