Third-stage syphilis and late-stage syphilis generally have a longer duration, with many cases exceeding two years. Third-stage syphilis can cause damage to the cardiovascular and nervous systems, and there may be residual symptoms after improvement. However, with persistent long-term standard treatment, it is still possible to achieve a cure. Therefore, if one contracts third-stage syphilis, it is crucial to adhere to the treatment and cooperate actively with the therapy.