Can a routine blood test detect whooping cough?

Written by Zeng Hai Jiang
Pediatrics
Updated on April 17, 2025
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Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis infection, commonly seen in children. The main symptoms are paroxysmal spasmodic coughing and a crowing inspiratory whoop. The disease has a long course and may be complicated by pneumonia, neurological diseases, and others. The diagnosis of the disease mainly relies on the cultivation of Bordetella pertussis, detection of Bordetella pertussis DNA, and testing for pertussis toxin antibodies. In this disease, the routine blood test will also show a significant increase in the white blood cell count, lymphocyte count, and white blood cell differential.

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Written by Li Jian Wu
Pulmonology
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What causes whooping cough?

Pertussis, also known as whooping cough, is a respiratory infectious disease primarily caused by the Bordetella pertussis or Corynebacterium diphtheriae bacteria. It is contagious and has a prolonged course, often leading to paroxysmal spasmodic coughing. It is commonly seen in infants and spreads through airborne droplets and close contact. The disease is generally prevented through vaccination. It has been included in the national free vaccination program, with babies receiving injections at three, four, and five months of age as part of their basic immunization, followed by a booster shot after the age of two. Once antibodies are produced, they can effectively prevent the disease.

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Written by Li Jian Wu
Pulmonology
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What does "one hundred days" in whooping cough refer to?

The clinical term "whooping cough" is so named because the term "hundred days" refers to the duration of the cough, symbolizing that the cough lasts a long time, the disease course is prolonged, and it tends to recur. It doesn’t necessarily mean that one will cough for exactly one hundred days. One should relax and have the correct understanding. For treating such diseases, sensitive antibiotics should be used promptly, along with symptomatic treatment. Blood tests such as a complete blood count and C-reactive protein should be conducted, along with chest X-ray, and sputum pathogen culture for definitive diagnosis, to ensure early detection and treatment.

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Written by Li Jian Wu
Pulmonology
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What is whooping cough?

Pertussis, also known as whooping cough, is a highly contagious respiratory tract infection. It primarily infects infants under the age of five, leading to distinctive coughing fits that are paroxysmal and may also include a barking cough or a crowing sound during inhalation. Some may also experience redness of the face and ears, runny nose, teary eyes, abdominal pain, nausea, and vomiting as complications. Upon observing these typical symptoms, it is advised to visit a hospital for appropriate diagnostic tests and timely symptomatic treatment, along with maintaining adequate hydration and keeping the indoor temperature comfortable.

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Written by Zeng Hai Jiang
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How to determine whether it is the paroxysmal stage or the recovery stage of pertussis?

After the incubation period, typical whooping cough goes through three clinical stages. The first stage is the catarrhal stage, also called the pre-paroxysmal stage, during which the infectivity is the strongest. If treated promptly during this stage, the progress of the disease can be controlled. If the catarrhal stage is not effectively controlled, it then enters the paroxysmal stage. During the paroxysmal stage, the patient will experience episodic spasmodic coughing, with more severe episodes at night. During spasms, there will be neck vein distension, swollen and congested eyelids and face, and cyanosis of the lips. This stage can last up to two months. After the paroxysmal stage follows the convalescent stage, where the episodic spasmodic coughing gradually decreases and becomes less severe.

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Written by Zeng Hai Jiang
Pediatrics
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How long does it usually take for the blood picture of pertussis to come down when it's too high?

Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis infection, commonly seen in children. The main clinical symptoms include typical paroxysmal spasmodic cough, crowing inspiratory whoop, with the cough being more prominent at night. In the peripheral blood, there will be a marked increase in white blood cell count, lymphocyte count, and lymphocyte classification. After a confirmed diagnosis of whooping cough, macrolide antibiotics are administered. After a week of aggressive treatment, the blood count typically decreases significantly.