What causes whooping cough?

Written by Li Jian Wu
Pulmonology
Updated on January 11, 2025
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Pertussis, also known as whooping cough, is a respiratory infectious disease primarily caused by the Bordetella pertussis or Corynebacterium diphtheriae bacteria. It is contagious and has a prolonged course, often leading to paroxysmal spasmodic coughing. It is commonly seen in infants and spreads through airborne droplets and close contact. The disease is generally prevented through vaccination. It has been included in the national free vaccination program, with babies receiving injections at three, four, and five months of age as part of their basic immunization, followed by a booster shot after the age of two. Once antibodies are produced, they can effectively prevent the disease.

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Written by Yan Xin Liang
Pediatrics
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Symptoms and Treatment of Whooping Cough in Children

The common symptoms of whooping cough are coughing, prolonged coughing, and spasmodic coughing, which ends with a crowing sound, and it mainly occurs during the night. The face may turn bright red during coughing, which is a typical symptom of whooping cough. For treatment, in the early stages of whooping cough, erythromycin is definitely used and can be effective. However, in pediatrics, if the whooping cough has lasted for a long time, the effectiveness of the treatment is relatively not as good. If the coughing period is long and medication is used in the middle to late stages, even with some treatment, it might still continue for two to three months. Although treatments like cough suppressants and expectorants can alleviate the symptoms, a cough usually still persists to some degree.

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Written by Li Jian Wu
Pulmonology
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Pertussis is diagnosed through what?

Whooping cough is a respiratory infectious disease, generally diagnosed through typical clinical symptoms and laboratory test results. Typical symptoms include paroxysmal, spasmodic coughing, which can also lead to flushed face and ears, runny nose, acute sickly appearance, while some patients may have a cough that sounds like a puppy's bark and others may exhibit a crowing sound during inhalation. During this period, sputum pathogen culture or other auxiliary examinations can be used for diagnosis, and sensitive antimicrobial drugs can be chosen for anti-inflammatory treatment.

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Written by Li Jian Wu
Pulmonology
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What does "one hundred days" in whooping cough refer to?

The clinical term "whooping cough" is so named because the term "hundred days" refers to the duration of the cough, symbolizing that the cough lasts a long time, the disease course is prolonged, and it tends to recur. It doesn’t necessarily mean that one will cough for exactly one hundred days. One should relax and have the correct understanding. For treating such diseases, sensitive antibiotics should be used promptly, along with symptomatic treatment. Blood tests such as a complete blood count and C-reactive protein should be conducted, along with chest X-ray, and sputum pathogen culture for definitive diagnosis, to ensure early detection and treatment.

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Written by Li Jian Wu
Pulmonology
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Is the pertussis vaccine a live vaccine?

The pertussis vaccine is a type of attenuated live vaccine, which clinically is mainly part of a combination vaccine that includes pertussis, diphtheria, and tetanus, commonly referred to as the DTP vaccine. Normally, a baby should receive the first dose at three months of age, followed by the second dose in the fourth and fifth months, as part of basic immunization. Between the age of eighteen months and two years, another dose is administered to boost immunity, which after producing lifelong antibodies, prevents reinfection with the disease.

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Written by Li Jian Wu
Pulmonology
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Where to treat whooping cough?

Pertussis, a respiratory infectious disease, is recommended to be checked and treated at local formal medical institutions. Once diagnosed, the main principle is to kill the Corynebacterium diphtheriae and choose sensitive antibiotics, such as macrolide antibiotics like erythromycin, azithromycin, or clarithromycin. Additionally, symptomatic treatment should be provided, including oxygen therapy for breathing difficulties, using medications to relieve bronchial smooth muscle spasms, thinning mucus, and alleviating uncomfortable symptoms such as coughing. It is also important to drink plenty of water, rest, and maintain good hygiene.