The symptoms of neurodermatitis primarily manifest as flat papules the size of pinpoints or rice grains on parts of the body such as the neck, sacral region, elbows, knees, inner thighs, perineum, and around the anus. The surface of these papules may have a small amount of scale and exhibit paroxysmal, intense itching. Due to this, a vicious cycle of itching and scratching can develop during the course of the disease, causing local skin lesions to merge into large patches. The skin becomes thicker and rougher, resembling lichenification, and shows episodes of severe itching.