Neurodermatitis, also known as chronic simple lichen, is a common chronic inflammatory skin disease characterized by paroxysmal severe itching and lichenoid changes in the skin, which are symptoms of a dysfunctional neurogenic disorder. The causes of the disease may be related to various internal and external factors such as neuropsychiatric factors, gastrointestinal dysfunction, endocrine disorders, local foreign body irritation, diet, etc. For neurodermatitis occurring on the eyelids, our first advice to patients is to avoid scratching and rubbing as much as possible, as these actions are major triggers or aggravating factors; secondly, use mild, minimally irritating topical medications such as moisturizing and anti-itch drugs, tar-based medications, and herbal ointments. It’s recommended to use corticosteroid creams sparingly or not at all. When applying medication, use them thinly and sparingly to minimize absorption due to the thin and highly vascular nature of the eyelid skin. In severe cases, oral antihistamines and calcium supplements can be used in combination.