Neurodermatitis, also known as chronic simple lichen, is a common chronic inflammatory skin disease characterized by episodic severe itching and lichenoid skin changes. It is a neurofunctional dermatosis, and its causes may be related to various internal and external factors, including neuropsychiatric factors, diet, gastrointestinal dysfunction, endocrine disorders, and local skin irritation. Currently, there are no clinical reports of neurodermatitis transforming into cancer, so it generally does not become cancerous.