Cervical cancer screening

Written by Gong Chun
Oncology
Updated on September 24, 2024
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For the examination of cervical cancer, it should be based on medical history and clinical manifestations, especially for people with contact vaginal bleeding, a detailed general examination and gynecological examination should be conducted, and an examination of cervical biopsy tissue is needed for diagnosis. What specific examinations are there? There are cervical scrape cytology tests, iodine tests, colposcopy, examination of cervical and cervical canal tissue, as well as post-surgical cervical conization, and examination of postoperative specimens. Therefore, there are indeed many examinations, including some radiological assessments such as enhanced CT, PADCT, MRI, and other such tests.

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Why would someone get cervical cancer?

Why does cervical cancer occur? There are several reasons for cervical cancer: The first is infection with the human papillomavirus, also known as HPV infection, which is the fundamental cause of precancerous lesions and cervical cancer. Secondly, there are other factors; in a few cases, HPV DNA is not detected in the tumor tissue, especially among elderly patients, and it is related to early childbirth and multiple pregnancies. The third point is that cervical cancer incidence is associated with high-risk males, including those who have had penile cancer, prostate cancer, or are high-risk individuals for cervical cancer. Women who are in contact with these high-risk men are more likely to develop cervical cancer. Lastly, irregular diet and lifestyle, along with smoking and drinking, can suppress the body's immune function, potentially promoting cancer.

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Late-stage symptoms of cervical cancer

The symptoms of advanced cervical cancer start with vaginal bleeding. In the later stages, the bleeding becomes irregular and possibly heavy. The second symptom is vaginal discharge. In advanced stages, due to cancerous tissue necrosis accompanied by infection, there can be a large amount of foul-smelling, watery, or purulent discharge. The third point about advanced symptoms depends on the extent of the cancerous area involved. Secondary symptoms may appear depending on the adjacent tissues, organs, and nerves affected, including frequent urination, urgency, constipation, swelling and pain in the lower limbs. When the tumor compresses or involves the ureter, it can cause ureteral obstruction, hydronephrosis, and uremia. In the advanced stages, patients may experience symptoms of systemic failure like anemia and cachexia.

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Cervical Cancer Staging Criteria

For the staging of cervical cancer, the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) are now adopted. Staging should be done before treatment, and since the FIGO staging of the cervix mainly relies on the examination of the pelvis, it is emphasized that the pelvic examination must be performed by two senior gynecologic oncologists. The staging primarily involves assessing the size of the cervical lesion, particularly the measurement of endophytic tumors, parametrial tissue infiltration, and the status of pelvic lymph nodes. However, these stages mainly rely on radiological examinations, primarily magnetic resonance imaging (MRI), to provide objective data for staging.

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Characteristics of Bleeding in Cervical Cancer

The bleeding characteristics of cervical cancer should be considered based on the pathological type and stage of the disease. In the early stages, the bleeding may be contact-related, occurring after sexual intercourse or a gynecological examination, and may involve a small amount of fresh, light bleeding. As the disease progresses into the later stages, the tumor may cause irregular vaginal bleeding. The amount of this irregular bleeding varies, depending on the size of the lesion and the involvement of the blood vessels in the interstitial tissues. A larger lesion may naturally result in more bleeding. In advanced stages, major blood vessels may be affected, potentially leading to severe bleeding. Therefore, the characteristics of vaginal bleeding should be analyzed based on the specific circumstances. If the cancer is exophytic, bleeding tends to occur earlier and is usually more copious, whereas if it is endophytic, bleeding tends to occur later.

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Causes of cervical cancer

The causes of cervical cancer are closely related to several factors. Firstly, infection with the human papillomavirus (HPV) is highly related and is the fundamental cause of precancerous lesions and cervical cancer. Secondly, although HPV DNA is not detected in the tumor tissues of a minority of cases, particularly among older patients, epidemiological surveys indicate that early childbirth and multiple childbearing are closely related to the incidence of cervical cancer. Thirdly, it has been found that the incidence of cervical cancer in women is related to contact with high-risk men, such as those with penile cancer, prostate cancer, or those whose ex-wives had cervical cancer. Fourthly, smoking has a certain relationship with the incidence of cervical cancer as it can inhibit the body's immune function. Alcohol consumption, irregular diet, and lifestyle also have certain relationships with the incidence of cervical cancer.