How to treat chronic atrophic gastritis with intestinal metaplasia?

Written by Si Li Li
Gastroenterology
Updated on January 23, 2025
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The treatment of chronic atrophic gastritis with intestinal metaplasia mainly includes the following aspects:

The first is general treatment. Firstly, the diet should be light and easily digestible, avoiding spicy, stimulating, fried, grilled, cold, and sweet foods. It is important to exercise regularly and avoid emotions such as anxiety and depression.

The second is the treatment against Helicobacter pylori, including a proton pump inhibitor plus two antibiotics, and a bismuth agent, with a treatment course of 14 days. Additionally, medications that promote gastric motility and protect the gastric mucosa are used.

The fourth involves endoscopic treatments, including endoscopic APC treatment or endoscopic mucosal resection.

The fifth, combining traditional Chinese medicine, differentiating syndrome treatments and oral herbal medicines, can also achieve good effects.

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Is the cancerous transformation of atrophic gastritis related to the duration of the disease?

The carcinogenesis of atrophic gastritis does not have a significant relationship with the duration of the disease. The main cause of atrophic gastritis is Helicobacter pylori infection, with autoimmune abnormalities and genetic factors also playing a significant role in atrophic gastritis. Sometimes, patients with a short duration of atrophic gastritis may also develop cancer, while those who have had the disease for many years may not necessarily develop cancer. Therefore, once atrophic gastritis is diagnosed, it is important to regularly re-examine with gastroscopy to rule out the possibility of early malignancy.

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How to prevent and treat atrophic gastritis

Chronic gastritis includes two types: chronic non-atrophic gastritis and chronic atrophic gastritis. Chronic atrophic gastritis is generally more severe than chronic non-atrophic gastritis and usually accompanies intestinal metaplasia, which some refer to as a precancerous lesion. If chronic atrophic gastritis is present, formal medical treatment is necessary. Initially, it is advisable to check for Helicobacter pylori infection. If an Helicobacter pylori infection is found, timely eradication therapy is recommended, typically using quadruple therapy, which consists of a proton pump inhibitor, two types of antibiotics, and a bismuth agent. If there is no Helicobacter pylori infection, treatment generally focuses on symptomatic relief, such as protecting the gastric mucosa and enhancing gastric motility. Additionally, traditional Chinese medicine has shown satisfactory effects in treating chronic atrophic gastritis. It is also important to maintain good dietary and living habits, prefer light and easily digestible foods, and avoid raw, greasy, spicy, and irritating foods to help maintain a positive state of mind. Regular gastroscopy check-ups are necessary. (Medication should be taken under the guidance of a doctor.)

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How to treat chronic non-atrophic gastritis with bile reflux?

For cases of chronic non-atrophic gastritis with bile reflux, it is first necessary to clarify whether there is a Helicobacter pylori infection, which can be determined by a breath test. Based on this, regular visits to the department of gastroenterology for diagnostics and treatment can be established. Firstly, it is important to take oral medication to protect the gastric mucosa and then to promote gastrointestinal motility. Regular follow-ups are very important. Generally, for patients with non-atrophic gastritis and bile reflux, it depends on whether the condition is high or low. For those in the high category, it is necessary to undergo a gastroscopy every six months.

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Is atrophic gastritis grade I serious?

Grade I atrophic gastritis is not serious. Atrophic gastritis refers to the atrophy and reduction of the gastric mucosa and glands, and it manifests with symptoms like stomach discomfort, bloating, stomach pain, and loss of appetite. For those with atrophic gastric cancer, it is important to control the diet, avoid overeating, and abstain from spicy, raw, greasy, and irritating foods. This type of chronic digestive system disease, if not properly managed, can frequently relapse and has the potential to become malignant. If the condition can be controlled and does not frequently recur, it generally does not have a significant impact on the body.

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Can chronic atrophic gastritis be cured?

Chronic atrophic gastritis is primarily a chronic digestive system disease caused by atypical hyperplasia. It is mainly characterized by upper abdominal dull pain, bloating, loss of appetite, weight loss, anemia, etc., and lacks specificity. It is a disease caused by multiple pathogenic factors and is a precancerous lesion. There are many causes, including Helicobacter pylori infection and dietary factors, among others. Moreover, treatment for atrophic gastritis can be targeted based on the specific condition, clinical symptoms, and auxiliary examinations.