What is the cause of recurrent atrophic gastritis?

Written by Wu Hai Wu
Gastroenterology
Updated on February 05, 2025
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Recurrent atrophic gastritis is likely caused by Helicobacter pylori infection. When atrophic gastritis recurs, a Carbon-13 urea breath test or Carbon-14 urea breath test should be conducted to detect whether there is an infection of Helicobacter pylori. If the test is positive, a two-week quadruple therapy containing a bismuth agent should be used to eradicate Helicobacter pylori. Consider using a proton pump inhibitor, such as omeprazole or lansoprazole, combined with two of the antibiotics amoxicillin, clarithromycin, metronidazole, and furazolidone, as well as bismuth citrate, to form the quadruple therapy. (Please use medication under the guidance of a doctor.)

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Written by Jiang Guo Ming
Gastroenterology
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How to effectively treat atrophic gastritis?

Relatively speaking, atrophic gastritis is much more serious than superficial gastritis. Treatment for this condition primarily depends on whether there is Helicobacter pylori infection. If there is Helicobacter pylori infection, a quadruple therapy is generally adopted to eradicate the bacteria, which can reverse some of the atrophy. If there is no Helicobacter pylori infection, treatment mainly involves symptomatic relief, such as protecting the gastric mucosa and increasing gastric motility, etc. Traditional Chinese medicine and herbal medicine also have relatively good effects on atrophic gastritis, often employing a comprehensive treatment after differential diagnosis. As for diet, it is recommended to eat light, easily digestible foods, eat at regular times and in small, frequent meals, and avoid stimulants like tobacco and alcohol, as well as raw, greasy, or spicy foods. (Please use medication under the guidance of a professional physician.)

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Written by Wu Hai Wu
Gastroenterology
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What are the symptoms before atrophic gastritis turns cancerous?

Patients with atrophic gastritis primarily exhibit symptoms such as dull pain, bloating, and burning pain in the upper abdomen, along with belching, acid reflux, weight loss, anemia, and more. If the pain from atrophic gastritis does not follow a clear pattern and is accompanied by progressive weight loss and refractory anemia, the possibility of cancerous changes in atrophic gastritis should be considered. It is advisable to promptly complete an endoscopy to confirm the diagnosis and rule out malignancy, and, if necessary, undertake a biopsy. In terms of treatment, it is first essential to test for Helicobacter pylori infection and then use medications to protect the gastric mucosa.

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Written by Wu Hai Wu
Gastroenterology
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Is the cancerous transformation of atrophic gastritis related to the duration of the disease?

The carcinogenesis of atrophic gastritis does not have a significant relationship with the duration of the disease. The main cause of atrophic gastritis is Helicobacter pylori infection, with autoimmune abnormalities and genetic factors also playing a significant role in atrophic gastritis. Sometimes, patients with a short duration of atrophic gastritis may also develop cancer, while those who have had the disease for many years may not necessarily develop cancer. Therefore, once atrophic gastritis is diagnosed, it is important to regularly re-examine with gastroscopy to rule out the possibility of early malignancy.

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Written by Si Li Li
Gastroenterology
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Is atrophic gastritis of the gastric antrum serious?

Atrophic gastritis is a chronic gastric disease characterized by repeated damage to the gastric mucosal epithelium, leading to the atrophy of the intrinsic glands, with or without intestinal metaplasia or pseudopyloric gland metaplasia. The main cause of this disease is infection by Helicobacter pylori. Symptoms primarily include upper abdominal distension, belching, acid reflux, early satiety, nausea, etc. Some patients may experience symptoms such as weight loss, fatigue, memory loss, anxiety, and depression. The main treatment involves eradicating Helicobacter pylori, suppressing acid production, and using gastric mucosal protectants and prokinetic agents. The majority of patients have Helicobacter pylori-related gastritis, which after chronic inflammation (chronic non-atrophic gastritis) can lead to atrophic gastritis, followed by intestinal metaplasia or dysplasia, and eventually may progress to gastric cancer.

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Written by Jiang Guo Ming
Gastroenterology
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Is nausea normal for atrophic gastritis?

Nausea is one of the common symptoms of gastrointestinal diseases, whether it is chronic superficial gastritis or atrophic gastritis. The occurrence of nausea usually indicates insufficient gastric motility. This condition is not considered normal, and targeted treatment is usually required depending on whether there is an infection with Helicobacter pylori. If there is an infection with Helicobacter pylori, it is first necessary to eradicate Helicobacter pylori. This generally involves quadruple therapy to eliminate the bacteria, accompanied by prokinetic agents, such as mosapride citrate. If there is no Helicobacter pylori infection, symptomatic treatment may suffice. For example, protecting the gastric mucosa and enhancing gastric motility, while also paying attention to daily dietary and lifestyle habits. (Note: The use of medications should be conducted under the guidance of a professional doctor.)