Is the cancerous transformation of atrophic gastritis related to the duration of the disease?

Written by Wu Hai Wu
Gastroenterology
Updated on February 19, 2025
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The carcinogenesis of atrophic gastritis does not have a significant relationship with the duration of the disease. The main cause of atrophic gastritis is Helicobacter pylori infection, with autoimmune abnormalities and genetic factors also playing a significant role in atrophic gastritis. Sometimes, patients with a short duration of atrophic gastritis may also develop cancer, while those who have had the disease for many years may not necessarily develop cancer. Therefore, once atrophic gastritis is diagnosed, it is important to regularly re-examine with gastroscopy to rule out the possibility of early malignancy.

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Written by Jiang Guo Ming
Gastroenterology
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Atrophic gastritis with intestinal metaplasia what medicine to take

Chronic atrophic gastritis with intestinal metaplasia often arises from untreated chronic superficial gastritis, primarily due to Helicobacter pylori infection. Therefore, it is essential to first check for Helicobacter pylori infection. If an infection is present, quadruple therapy is generally used to eradicate the bacteria, which may improve the atrophy. If there is no Helicobacter pylori infection, treatment mainly involves protecting the gastric mucosa. While there are no specific Western medicines for this, traditional Chinese medicine and a differential diagnosis approach often yield good results. Regular follow-ups are also important. (Specific medications should be used under the guidance of a doctor.)

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Written by Si Li Li
Gastroenterology
1min 9sec home-news-image

Is atrophic gastritis easy to treat?

Atrophic gastritis is a type of chronic gastritis characterized by the atrophy of gastric mucosal glands. It carries a certain risk of becoming cancerous. The main symptoms include upper abdominal pain, postprandial fullness, heartburn, indigestion, belching, and acid reflux. Gastroscope examination reveals atrophy of the gastric glands, and a biopsy is needed for a pathological examination to confirm the diagnosis of chronic atrophic gastritis. In terms of treatment, the first step is to eradicate Helicobacter pylori, which includes a regimen of one proton pump inhibitor, two antibiotics, and one bismuth agent, lasting for 14 days. This is followed by acid suppression and mucosal repair treatments. Additionally, the treatment with traditional Chinese medicine plays a significant role in managing atrophic gastritis. This condition is challenging to treat, has poor outcomes, is prone to relapse, and carries a risk of cancer transformation.

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Written by Si Li Li
Gastroenterology
1min 12sec home-news-image

Chronic non-atrophic gastritis

Chronic non-atrophic gastritis is also known as chronic superficial gastritis. It is a classification of chronic gastritis, which also includes chronic atrophic gastritis and special types of gastritis as other classifications. Chronic non-atrophic gastritis refers to a condition where the glands in the gastric mucosa do not show atrophy, thus it is called chronic non-atrophic gastritis. Generally, the endoscopic appearance of the gastric mucosa being hyperemic, edematous, or eroded can lead to a diagnosis of chronic non-atrophic gastritis. Treatment mainly focuses on acid suppression, protecting the stomach, promoting gastric motility, and protecting the gastric mucosa. If there is a positive Helicobacter pylori infection, eradication treatment for Helicobacter pylori is required. Patients with chronic non-atrophic gastritis should primarily consume a light and easy-to-digest diet.

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Written by Wu Hai Wu
Gastroenterology
38sec home-news-image

Is the cancerous transformation of atrophic gastritis related to the duration of the disease?

The carcinogenesis of atrophic gastritis does not have a significant relationship with the duration of the disease. The main cause of atrophic gastritis is Helicobacter pylori infection, with autoimmune abnormalities and genetic factors also playing a significant role in atrophic gastritis. Sometimes, patients with a short duration of atrophic gastritis may also develop cancer, while those who have had the disease for many years may not necessarily develop cancer. Therefore, once atrophic gastritis is diagnosed, it is important to regularly re-examine with gastroscopy to rule out the possibility of early malignancy.

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Written by Huang Gang
Gastroenterology
37sec home-news-image

"Mild active phase of atrophic gastritis"

Mild active phase of atrophic gastritis refers to the period when gastritis is occurring, typically caused by improper diet. This might be due to overeating or consuming greasy, spicy, and irritating foods, leading to exacerbation of the condition. Clinical manifestations include stomach pain, nausea, vomiting, and decreased appetite, which are inevitably linked to daily life habits. Furthermore, mental stress, excessive pressure, staying up late, and overfatigue can also have an impact.