Can atrophic gastritis lead to gastric cancer?

Written by Gong Chun
Oncology
Updated on September 27, 2024
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The development of gastric cancer, particularly intestinal-type gastric cancer, is a multi-stage process influenced by various factors. Chronic atrophic gastritis is primarily characterized by the atrophy and reduction of gastric mucosal glands. Consequently, it often accompanies varying degrees of metaplasia in the gastrointestinal mucosal epithelium. Chronic atrophic gastritis features a reduction in B cells of the gastric glands, and the pH value of gastric juice may increase. Hence, the relationship between chronic atrophic gastritis and gastric cancer is significant, as it is considered a precancerous lesion. Therefore, if one has atrophic gastritis, it is crucial to seek timely medical treatment to prevent worsening of the condition.

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Written by Wu Hai Wu
Gastroenterology
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Is the cancerous transformation of atrophic gastritis related to the duration of the disease?

The carcinogenesis of atrophic gastritis does not have a significant relationship with the duration of the disease. The main cause of atrophic gastritis is Helicobacter pylori infection, with autoimmune abnormalities and genetic factors also playing a significant role in atrophic gastritis. Sometimes, patients with a short duration of atrophic gastritis may also develop cancer, while those who have had the disease for many years may not necessarily develop cancer. Therefore, once atrophic gastritis is diagnosed, it is important to regularly re-examine with gastroscopy to rule out the possibility of early malignancy.

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Written by Wu Hai Wu
Gastroenterology
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What is the cause of recurrent atrophic gastritis?

Recurrent atrophic gastritis is likely caused by Helicobacter pylori infection. When atrophic gastritis recurs, a Carbon-13 urea breath test or Carbon-14 urea breath test should be conducted to detect whether there is an infection of Helicobacter pylori. If the test is positive, a two-week quadruple therapy containing a bismuth agent should be used to eradicate Helicobacter pylori. Consider using a proton pump inhibitor, such as omeprazole or lansoprazole, combined with two of the antibiotics amoxicillin, clarithromycin, metronidazole, and furazolidone, as well as bismuth citrate, to form the quadruple therapy. (Please use medication under the guidance of a doctor.)

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Written by Xie Zheng Yuan
Gastroenterology
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How long does it take to treat atrophic gastritis with erosion?

Atrophic gastritis with erosion is a type of chronic gastritis and has a lengthy course of disease. Through treatment, the erosions may heal within six to eight weeks. However, reversing the atrophy of the gastric mucosa is a long-term and slow process, and there are no specific effective drugs clinically available. Some traditional Chinese medicines and proprietary Chinese medicines may be effective, but it typically takes at least six months. Therefore, the duration required to treat atrophic gastritis with erosion varies from person to person, depending on individual differences.

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Written by Si Li Li
Gastroenterology
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Chronic non-atrophic gastritis

Chronic non-atrophic gastritis is also known as chronic superficial gastritis. It is a classification of chronic gastritis, which also includes chronic atrophic gastritis and special types of gastritis as other classifications. Chronic non-atrophic gastritis refers to a condition where the glands in the gastric mucosa do not show atrophy, thus it is called chronic non-atrophic gastritis. Generally, the endoscopic appearance of the gastric mucosa being hyperemic, edematous, or eroded can lead to a diagnosis of chronic non-atrophic gastritis. Treatment mainly focuses on acid suppression, protecting the stomach, promoting gastric motility, and protecting the gastric mucosa. If there is a positive Helicobacter pylori infection, eradication treatment for Helicobacter pylori is required. Patients with chronic non-atrophic gastritis should primarily consume a light and easy-to-digest diet.

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Written by Feng Ying Shuai
Traditional Chinese Medicine
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Where to apply moxibustion for atrophic gastritis?

For some symptoms of atrophic gastritis, moxibustion can be applied, such as on the Zhongwan acupoint located on the Ren meridian, as well as the Xiawan and Liangqiu acupoints. Moxibustion can also be done on the Zusanli acupoint along the stomach meridian, as well as on Neiguan and Gongsun acupoints, which are intersections of the eight meridians and can regulate atrophic gastritis. However, there is a particular method to follow during moxibustion; generally, acupoints on the upper body are treated first, followed by those on the lower body. For instance, start with the acupoints on the abdomen such as Zhongwan, Xiawan, and Liangqiu, followed by Zusanli, and then Gongsun. During moxibustion, the amount of moxa used should increase gradually, and the duration of treatment should extend from short to longer periods, indicating that the treatment period for atrophic gastritis might be longer.