What should I do if I feel uncomfortable in my stomach and intestines after treatment for Helicobacter pylori?

Written by Wu Hai Wu
Gastroenterology
Updated on February 26, 2025
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The main reason for discomfort in the stomach and intestines after treatment for Helicobacter pylori might very likely be due to the consumption of clarithromycin, metronidazole, etc., as metronidazole, clarithromycin, and others can also irritate the gastrointestinal tract. Therefore, it is recommended to take metronidazole, clarithromycin, and other similar medications about half an hour after meals to reduce their side effects. If the patient experiences gastrointestinal discomfort, consider using medications that regulate the gut flora for treatment, such as compounded lactobacillus, bifidobacterium triple live bacteria, and bacillus coagulans, etc.

If the stomach discomfort is quite severe, medications that protect the gastric mucosa, such as magnesium trisilicate or vitamin B6, may be taken. These medications can help alleviate the side effects of other drugs and reduce symptoms of nausea and vomiting.

Discomfort might also be due to incomplete healing. First, it is necessary to return to a regular hospital for a follow-up consultation. If the symptoms have not worsened, it is important to continue taking the prescribed medications as advised by the doctor. Recent dietary habits should include eating regularly, having smaller, more frequent meals, and avoiding spicy, stimulating, and greasy foods. Rest should also be prioritized.

(Please follow medical advice when using medications.)

Other Voices

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Do you need to change your toothbrush when treating Helicobacter pylori?

It is recommended to change your toothbrush during the treatment period for Helicobacter pylori. This is because Helicobacter pylori exists not only in the stomach but can also be detected in the saliva, dental plaque, and tongue coating of the mouth. Once infected with Helicobacter pylori, a two-week quad therapy that includes bismuth agents is necessary to eradicate the infection. After eradication, the bacteria might still be present on the toothbrush, which could lead to a recurring infection. Therefore, it is advised that patients change their toothbrush after undergoing treatment for Helicobacter pylori. Patients infected with Helicobacter pylori should undergo the two-week quad therapy including bismuth agents for treatment.

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Does superficial gastritis infected with Helicobacter pylori need treatment?

Superficial gastritis, after infection with Helicobacter pylori, requires treatment. If not actively symptomatic treated, the condition can worsen and frequently relapse, increasing the risk of malignancy. For superficial gastritis with Helicobacter pylori, initial treatment can involve natural therapies to control and eradicate Helicobacter pylori completely. Subsequently, based on individual clinical symptoms, treatment should focus on chronic superficial gastritis. Regular maintenance primarily involves being cautious with diet, avoiding spicy foods, and refraining from consuming food that is too cold, too sweet, too hard, or too acidic, as well as overly stimulating foods.

doctor image
home-news-image
Written by Wu Hai Wu
Gastroenterology
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What should I do if I feel uncomfortable in my stomach and intestines after treatment for Helicobacter pylori?

The main reason for discomfort in the stomach and intestines after treatment for Helicobacter pylori might very likely be due to the consumption of clarithromycin, metronidazole, etc., as metronidazole, clarithromycin, and others can also irritate the gastrointestinal tract. Therefore, it is recommended to take metronidazole, clarithromycin, and other similar medications about half an hour after meals to reduce their side effects. If the patient experiences gastrointestinal discomfort, consider using medications that regulate the gut flora for treatment, such as compounded lactobacillus, bifidobacterium triple live bacteria, and bacillus coagulans, etc. If the stomach discomfort is quite severe, medications that protect the gastric mucosa, such as magnesium trisilicate or vitamin B6, may be taken. These medications can help alleviate the side effects of other drugs and reduce symptoms of nausea and vomiting. Discomfort might also be due to incomplete healing. First, it is necessary to return to a regular hospital for a follow-up consultation. If the symptoms have not worsened, it is important to continue taking the prescribed medications as advised by the doctor. Recent dietary habits should include eating regularly, having smaller, more frequent meals, and avoiding spicy, stimulating, and greasy foods. Rest should also be prioritized. (Please follow medical advice when using medications.)

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Written by Si Li Li
Gastroenterology
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Can Helicobacter pylori infection recur after treatment?

Helicobacter pylori, once treated, does not recur, but it is possible to be infected again after the treatment is completed. Currently, the infection rate of Helicobacter pylori in our country has exceeded 50%, so it is important to be cautious during communal meals. Due to the Chinese dietary habit of sharing dishes using the same chopsticks, it is easy to spread Helicobacter pylori. Therefore, it is advisable to use serving chopsticks, which can significantly reduce the infection rate of Helicobacter pylori. If reinfected with Helicobacter pylori, it is necessary to undergo eradication treatment again. The treatment involves a proton pump inhibitor, two types of antibiotics, and a bismuth agent, totaling a 14-day treatment. After infection with Helicobacter pylori, dietary precautions are also needed, focusing on a light, easily digestible diet, and avoiding difficult-to-digest foods.

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How to treat Helicobacter pylori positivity?

A positive test for Helicobacter pylori requires distinguishing the specific method used for detection. If it is a positive result from a Helicobacter pylori antibody test, a breath test, including both the Carbon-14 and Carbon-13 breath tests, should be conducted. If the breath test comes back positive, further examinations are necessary, including gastroscopy and analysis of Helicobacter pylori virulence factors. The analysis of virulence factors can help determine if the Helicobacter pylori infection is highly toxic. If positive, it may indicate a potential for severe gastric diseases and necessitate treatment. For individuals with a positive Helicobacter pylori breath test, a gastroscopy is also recommended, as it is the only way to precisely determine the type of gastric disease present, such as ulcers or gastritis. Depending on the gastroscopy results, some individuals may need eradication treatment for Helicobacter pylori, especially those with a history of gastric ulcers, a family history of gastric cancer, gastric polyps, erosive gastritis, or gastric mucosa-associated lymphoid tissue lymphoma. Others, if the virulence factor analysis is negative, might not require immediate treatment for Helicobacter pylori. However, if a patient insists on treatment for Helicobacter pylori, it can be considered, but it must be clear that there are risks involved and that the treatment should be conducted properly. Finally, treatment for Helicobacter pylori is not recommended for minors, i.e., individuals under 18 years of age.