How is Alzheimer's disease treated?

Written by Zhang Hui
Neurology
Updated on September 11, 2024
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Senile dementia, also known as Alzheimer's disease, is the most common neurodegenerative disease worldwide. The pathogenesis of this disease is not particularly clear so far and may be related to genetic and environmental factors. Multiple factors act on neurons causing irreversible and progressive death of neuronal cells. Currently, the treatment of this disease mainly includes two aspects. The first aspect is general treatment, mainly including family care. Family members must pay attention to the care of the patient, prevent the patient from accidentally wandering off, prevent the patient from falling, and prevent some accidents that cause injuries. In addition, it is important for the patient to listen to music, interact with others, and exercise more, all of which can delay the progression of senile dementia. The second aspect is pharmacological treatment, mainly using drugs that inhibit the reduction of acetylcholine. These drugs can increase the content of acetylcholine and improve the cognitive functions of patients to a certain extent, but so far, these treatments cannot reverse senile dementia.

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Written by Zhang Hui
Neurology
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Determination of Senile Dementia

The assessment of dementia primarily encompasses three aspects: The first aspect mainly involves relevant neurological scales, which can scientifically and effectively measure the cognitive functions of elderly patients. These scales include the MSE (Mini-Mental State Examination) and the MoCA (Montreal Cognitive Assessment). The second aspect of the assessment involves some imaging tests, mainly cranial MRI scans. Cranial MRI can determine if there is brain atrophy in the elderly and examine for any related lesions in the temporal lobes and hippocampi. The third major aspect involves the analysis of cerebrospinal fluid, assessing the levels of amyloid proteins, which also play an important role in the assessment of dementia. In summary, the assessment of dementia primarily involves evaluations using neurological scales, cranial MRI, and cerebrospinal fluid analysis.

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Written by Zhang Hui
Neurology
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Alzheimer's disease is also called dementia.

Alzheimer's disease, also known as dementia in the elderly, was first identified abroad and thus named after the discoverer, Alzheimer. It is one of the most common neurodegenerative diseases in neurology, with a very high incidence among people over 65 in China and worldwide. The disease mainly affects patients' cognitive functions. Initially, patients do not meet the criteria for dementia and primarily exhibit a decline in memory. As the disease progresses, the decline in memory worsens, and patients begin to forget both recent and past events. Additionally, they may experience impairments in visuospatial abilities, judgment, comprehension, and learning capabilities. In the later stages, psychiatric symptoms and personality changes may appear, such as visual hallucinations, shouting, and gesturing wildly, among various other clinical manifestations.

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Written by Zhang Hui
Neurology
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probability of senile dementia

Dementia primarily refers to Alzheimer's disease, which has a relatively high incidence rate. In China, among the elderly population over 65 years old, approximately 3% to 7% are affected; this rate can rise to over 20% among those over 85 years old. Suffering from dementia places a heavy burden on the patient, their family, and society. Initially, patients with dementia will experience a decline in memory function. As the condition progresses, there will be a decline in various cognitive functions. For example, spatial dysfunction might occur, such as getting lost on the way home, personality changes, and the emergence of psychiatric symptoms and other clinical manifestations.

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Written by Zhang Hui
Neurology
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What to do about senile dementia?

When dementia occurs in the elderly, there is a noticeable decline in cognitive function. Initially, it is important to identify the cause of the dementia; some cerebrovascular diseases can also cause dementia. For example, cerebral infarction in certain specific areas of the brain can lead to dementia if it affects the intelligence center. For dementia caused by these reasons, it is recommended to treat with antithrombotic medications, including antiplatelet aggregation drugs and brain cell protective medications. Additionally, if the dementia is caused by Alzheimer's disease, close care is needed to prevent incidents like the patient getting lost. It is advisable to write contact numbers in the pockets of their clothes and administer acetylcholinesterase inhibitors to increase the levels of acetylcholine in the brain, which can improve cognitive function to a certain extent. (Note: This answer is for reference only. Medication should be prescribed and managed under the guidance of a professional physician, and self-medication should be avoided.)

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Written by Zhang Hui
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symptoms of senile dementia

The symptoms of dementia mainly include the following aspects: First, there is evident impairment in cognitive functions, primarily involving memory decline. Initially, it may predominantly affect recent memory, with patients often forgetting recent events. As the disease progresses, they may start forgetting events from the distant past as well. Additionally, patients may experience a decline in calculation skills, judgment, execution, and comprehension abilities; their capacity to learn and work is comprehensively impaired. Spatial dysfunction can also occur, causing disorientation and frequent episodes of getting lost. Secondly, in the later stages, patients may display changes in behavior and personality, alongside corresponding psychological symptoms. For example, the patient might become aggressive, restless, and exhibit hallucinations visually and auditorily. Wandering at night is another common symptom. Thirdly, in the later stages, patients might show clinical signs such as muscle atrophy and paralysis. Incontinence is also a common symptom.