The symptoms of late-stage bladder cancer include: 1. Difficulty urinating. Due to the large size of the tumor, its location at the neck of the bladder, or the formation of blood clots, there can be blockage of urine flow, difficulty urinating, and even urinary retention. 2. Bladder irritation symptoms. Early-stage bladder often shows fewer urinary irritation symptoms, but when the tumor occurs in the trigone area of the bladder, urinary irritation symptoms may appear earlier. There are also symptoms of upper urinary tract obstruction, such as when the cancer invades the ureteral orifice, causing dilation and accumulation of fluid in the renal pelvis and ureter, and even infections leading to backache, waist pain, fever, etc. Additionally, there are general symptoms, including nausea, reduced appetite, fever, weight loss, anemia, cachexia, and more.