Sinus arrhythmia, if it manifests as sick sinus syndrome, can lead to symptoms of insufficient blood supply to organs such as the heart, brain, and kidneys. These symptoms include episodic dizziness, dim vision, palpitations, fatigue, and decreased exercise tolerance. In severe cases, there may be angina, heart failure, transient loss of consciousness or syncope, and even sudden death.

If there is an episode of tachycardia, symptoms such as palpitations and angina can occur. If the symptoms are significant, consideration may be given to pacemaker therapy. Sinus tachycardia and sinus bradycardia can be physiological or pathological. Physiological cases generally do not show symptoms, are not harmful, and do not require treatment. Pathological cases primarily focus on treating the underlying disease.