Acne and folliculitis, although both are skin diseases, have significant differences. Firstly, acne is caused by bacteria such as Propionibacterium acnes, while folliculitis is mainly caused by Staphylococcus aureus infection. Secondly, their treatments differ. Finally, the symptoms of acne and folliculitis are also different. Generally, folliculitis does not occur frequently, whereas acne does. Folliculitis initially presents as red papules that progress to pustules. Acne, on the other hand, displays various forms including papules, pustules, as well as blackheads and whiteheads.