Viral hepatitis, especially in cases where the condition is particularly severe, bilirubin levels are particularly high, and coagulation function is particularly poor, may require plasma treatment. This involves the administration of plasma and nutritional support as symptomatic supportive therapy. Some patients may also need plasma exchange and artificial liver treatment. The treatment of viral hepatitis should aim to remove the cause of the disease as much as possible while also strengthening liver protection and enzyme reduction therapies. Severe cases may require plasma treatment. Treatment decisions should be based on the actual situation and starting treatment early in the onset of the disease can stabilize most conditions.