Is aplastic anemia serious?

Written by Li Fang Fang
Hematology
Updated on September 10, 2024
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Whether aplastic anemia is severe depends on the specific circumstances of the aplastic anemia. Aplastic anemia can be divided into acute aplastic anemia and chronic aplastic anemia. Among them, acute aplastic anemia has a sudden onset, more severe clinical symptoms, and a higher mortality rate, so it is relatively more severe. Chronic aplastic anemia has a slower onset, and the degree of decrease in blood cells is relatively mild, also making it less severe. However, in cases of acute aplastic anemia, if intensive immunotherapy is administered, the effectiveness can reach 60%-70%, and it can be cured through hematopoietic stem cell transplantation.

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Written by Li Fang Fang
Hematology
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Can aplastic anemia be cured completely?

Aplastic anemia clinically is categorized into acute aplastic anemia and chronic aplastic anemia. Acute aplastic anemia appears suddenly and is severe, with a short survival period. Chronic aplastic anemia develops slowly, has a longer history, and is relatively milder in condition. Whether it is acute aplastic anemia or chronic aplastic anemia, curative treatment can only be achieved through allogeneic hematopoietic stem cell transplantation. Although allogeneic hematopoietic stem cell transplantation offers a potential cure for aplastic anemia, there is also a certain rate of failure. Additionally, post-transplant, there is a presence of immune rejection.

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Can aplastic anemia have children?

Acute aplastic anemia, after effective immunotherapy and discontinuation of medication for more than two years, or after hematopoietic stem cell transplantation and discontinuation of medication for more than two years, it is possible to have children. In cases of chronic aplastic anemia, due to long-term oral intake of immunosuppressants and hematopoietic stimulants, having children is not advised. However, if immunosuppressants and hematopoietic drugs are effective and discontinued for more than two years, and blood levels are acceptable, then it is possible to have children.

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Aplastic anemia is classified into several types.

Aplastic anemia is divided into two types: acute aplastic anemia and chronic aplastic anemia. Acute aplastic anemia presents suddenly and is severe. Treatment requires intensified immunotherapy or suppression of hematopoietic stem cell transplantation. Chronic aplastic anemia develops slowly, has a longer history, and is relatively less severe. The treatment for chronic aplastic anemia mainly involves immunotherapy combined with therapy to promote hematopoiesis. In addition, regardless of the type, all cases of aplastic anemia require regular complete blood count checks and, when necessary, supportive treatment with red blood cell and platelet transfusions.

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Written by Li Fang Fang
Hematology
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The etiology of aplastic anemia

The etiology of aplastic anemia currently has no absolute cause, but the more supported theories concerning its etiology include the soil, pest, and seed theories. The soil theory refers to abnormalities in the microenvironment within the bone marrow, which causes an abnormal growth environment for hematopoietic stem cells, consequently limiting their growth. The seed theory indicates a decrease in the number and quality of hematopoietic stem cells in the bone marrow, leading to bone marrow regeneration failure. The pest theory refers to immunological factors, which play a significant role in aplastic anemia, suggesting a disorder in the patient's immune function that leads to bone marrow regeneration failure.

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Written by Li Fang Fang
Hematology
52sec home-news-image

Is aplastic anemia serious?

Whether aplastic anemia is severe depends on the specific circumstances of the aplastic anemia. Aplastic anemia can be divided into acute aplastic anemia and chronic aplastic anemia. Among them, acute aplastic anemia has a sudden onset, more severe clinical symptoms, and a higher mortality rate, so it is relatively more severe. Chronic aplastic anemia has a slower onset, and the degree of decrease in blood cells is relatively mild, also making it less severe. However, in cases of acute aplastic anemia, if intensive immunotherapy is administered, the effectiveness can reach 60%-70%, and it can be cured through hematopoietic stem cell transplantation.