Treatment methods for leukopenia

Written by Zhao Xin Lan
Endocrinology
Updated on September 11, 2024
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First, it is necessary to identify the cause of leukopenia. Common causes include viral infections and poor bone marrow hematopoiesis, and some medications can also cause this condition. Therefore, symptomatic treatment mainly involves the use of medications that increase white blood cells. For mild leukopenia, oral medications commonly used include Li Xuesheng, squalene, and Vitamin B4 to promote the proliferation of white blood cells. In more severe cases, granulocyte colony-stimulating factors may be used. Of course, the main method of treatment still depends on the different causes of each patient. Once leukopenia occurs, it is necessary to go to the hospital for an examination to clearly determine the cause of the decrease in white blood cells, so that targeted treatment can be provided. (Please use medications under the guidance of a professional physician and do not self-medicate.)

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Written by Zhang Xiao Le
Hematology
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Symptoms of leukopenia

The symptoms of leukopenia vary with the severity of the decrease in white blood cells and the disease causing the leukopenia. Mild leukopenia generally has no significant clinical manifestations. With moderate leukopenia, patients often experience symptoms of fatigue. If there is a significant decrease in white blood cells, patients often present with fever since white blood cells are the main cells in the body's defense against infections. A significant decrease in white blood cells markedly lowers the patient's resistance, thus making them more susceptible to various infections, with fever being the most common symptom of infection. Furthermore, the clinical presentations also vary with the underlying disease causing the decrease in white blood cells. For example, diseases like aplastic anemia or acute leukemia, which cause a decrease in white blood cells, may lead not only to fever but also to significant fatigue and bleeding manifestations.

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Written by Yang Li
Endocrinology
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Can leukopenia cause fever?

Leukopenia can lead to fever. White blood cells are the guardians of the human body, protecting it against external invasions such as infections. When white blood cells are decreased, the patient's resistance to infections can be significantly reduced, making them particularly susceptible to infections. This can lead to fever, as often seen in hematological patients with leukopenia who frequently experience fevers due to their chronic infection states. Therefore, when leukopenia is accompanied by fever, it is advisable to seek hospital treatment as soon as possible, as proactive infection management is crucial.

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Written by Liu Lei
Endocrinology
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What causes leukopenia?

Leukopenia mainly has the following three causes: 1) Drugs; 2) Infections; 3) Diseases that cause disturbances in white blood cell production. Drugs primarily include antibiotics such as sulfonamide antibiotics and penicillin; anti-tuberculosis drugs like rifampicin and isoniazid; anti-thyroid drugs such as methimazole and propylthiouracil; antipyretic analgesics like aminopyrine, indomethacin, and ibuprofen; and antihistamines such as diphenhydramine. Additionally, most chemotherapy drugs can cause a decrease in white blood cells. Viral infections can lead to a decrease in white blood cells or severe bacterial infections, such as sepsis and septicemia, along with some chronic infections. Diseases that cause disturbances in the production of white blood cells mainly refer to certain hematological diseases, such as aplastic anemia or malignant tumors that invade the bone marrow and affect hematopoiesis. Furthermore, there are some less common causes of leukopenia, such as familial inheritance and granulocyte distribution disorders.

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Written by Zhang Jun Jun
Endocrinology
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What does a decrease in white blood cells mean?

Leukopenia indicates a decrease in the body's resistance. The most common causes of leukopenia are: First, viral infections, which often coincide with an increase in lymphocytes and a decrease in neutrophils. The second cause is severe bacterial infections. During severe bacterial infections, there is a significant reduction in white blood cells, which may even lead to a decrease in platelets. The third cause is primarily diseases of the hematologic system, where leukopenia is often accompanied by a reduction in other red blood cells and platelets. Other possible causes include drug-induced leukopenia, as medications can also lead to a decrease in white blood cells. Therefore, the primary approach to leukopenia is to clearly identify the cause, and then determine the next steps for treatment based on that cause.

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Written by Li Lang Bo
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Is leukopenia severe?

The normal value of white blood cells in the human body is 4 to 10×10^9/L. White blood cells mainly consist of neutrophils and lymphocytes, along with some other types of eosinophilic and basophilic granulocytes. If the total white blood cell count decreases, generally falling below 4 to 10×10^9/L, it is referred to as leukopenia. Among these, neutrophils are the most related to the body's immune response. If neutrophils decrease to less than 1.5×10^9/L, it is defined as neutropenia, which is very serious. If neutropenia occurs, the resistance to infections is greatly lowered, making the body highly susceptible to various infections. Active treatment to increase white blood cells is necessary; otherwise, any infection may lead to severe conditions like septicemia and septic shock, which can even be life-threatening.