What are the causes of leukopenia?

Written by Tang Zhuo
Endocrinology
Updated on August 31, 2024
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When the white blood cell count in peripheral blood is below 4.0 times 10 to the ninth power per liter, it is termed leukopenia. According to the cause, it can be divided into the following three aspects: First, disturbance in the production of white blood cells, including reduced proliferation of stem cells or regeneration disorders. Second, excessive destruction of white blood cells, such as from infections or immunological factors, leading to increased destruction of white blood cells. Third, abnormal distribution of white blood cells, due to various reasons, causes an increase in white blood cells in the marginal pool and a decrease in the circulating pool, which can also lead to leukopenia.

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Written by Zhang Jun Jun
Endocrinology
2min 27sec home-news-image

What to eat to quickly recover from leukopenia?

There are mainly three reasons for leukopenia: the first is the impaired production of white blood cells, the second is the excessive destruction of white blood cells, and the third is the redistribution of white blood cells. Therefore, for leukopenia, the main approach is etiological treatment. If leukopenia is suspected to be caused by certain drugs or other pathogenic factors, generally, stopping the use of these drugs and avoiding contact can lead to the recovery of white blood cells to normal levels. For this kind of secondary decrease of white blood cells, we usually treat the primary disease. Once the symptoms of the primary disease are alleviated and controlled, the white blood cell count can return to normal without the need for additional medication. Moreover, the greatest risk of leukopenia is the fear of infection, but mildly reduced patients generally do not require special treatment. However, as the severity of leukopenia increases, the risk of infection increases, and at this point, some preventative measures against infection can be taken. Particularly for patients with neutropenia who are highly susceptible to severe infections, sterile isolation may be employed, and the specific sites and types of infections identified. This allows for the use of sensitive antibiotics; for viral infections, antiviral drugs can be administered. Additionally, broad-spectrum antibiotics capable of covering both Gram-negative and Gram-positive bacteria can be used. Furthermore, while preventing infection, it is also important to promote the production of granulocytes. This typically requires ruling out serious hematologic diseases before using medications that promote white blood cell production, such as B vitamins and squalene. However, these treatments are only symptomatic. The primary focus should still be on correcting the underlying cause to maintain white blood cells within a normal range. (Please consult a doctor before using any medication and do not self-medicate.)

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Written by Tang Zhuo
Endocrinology
1min 15sec home-news-image

What are the symptoms of leukopenia?

Leukopenia is a common hematological disorder that can occur at any age. It is defined as leukopenia when the total number of white blood cells in the peripheral blood consistently falls below four times ten to the ninth power per liter. The onset of this disease is usually gradual with mild symptoms such as fatigue, palpitations, dizziness, low fever, prone to pharyngitis or mucosal ulcerations, and also includes loss of appetite, limb fatigue, insomnia with frequent dreams, and a cold stomach and backache. It makes one more susceptible to viral and bacterial infections such as colds. If leukopenia is caused by an infection, common symptoms include high fever, chills, and body aches. If the total number of white blood cells is significantly reduced, with an absolute neutrophil count below 0.5 times ten to the ninth power per liter, it is referred to as neutropenia. In such cases, the patient may experience chills, high fever, sore throat, headache, joint pain, and in severe cases, even coma and death.

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Written by Yang Li
Endocrinology
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Does leukopenia lead to leukemia?

First of all, a concept to clarify: generally, leukemia is associated with a very high white blood cell count. So, does a decrease in white blood cells lead to leukemia? There is no direct causal relationship between the two. A reduction in white blood cells generally requires an analysis of its cause—whether it is due to a decline in hematopoietic function, a deficiency in raw materials, or an increase in destruction. These situations essentially involve issues in the production factory or where they are used. We cannot say that people with reduced white blood cells will not develop leukemia, nor can it be stated in that way. They may also, over a period, exhibit a reduction in white blood cells due to certain factors. So, if there are genes causing leukemia combined with other factors, leukemia might occur, but there is no direct causation between the two.

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Written by Yang Li
Endocrinology
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Why does pneumonia cause a decrease in white blood cells?

When the severity of pneumonia is very severe, there can also be a decrease in white blood cells, which often suggests a higher possibility of severe pneumonia. Additionally, another scenario is viral pneumonia, where a decrease in white blood cells can also occur due to viral infections. Furthermore, there are special cases of infection, such as tuberculosis or infections caused by Mycoplasma or Chlamydia, where the use of anti-infection medications might also lead to a decrease in white blood cells. Another situation is when a patient inherently has a low white blood cell count, leading to weakened immunity and subsequently contracting pneumonia. In such cases, white blood cell counts might also not be high. Hence, severe bacterial pneumonia and decreases in white blood cells are relatively common in viral infections.

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Written by Tang Zhuo
Endocrinology
49sec home-news-image

What are the causes of leukopenia?

When the white blood cell count in peripheral blood is below 4.0 times 10 to the ninth power per liter, it is termed leukopenia. According to the cause, it can be divided into the following three aspects: First, disturbance in the production of white blood cells, including reduced proliferation of stem cells or regeneration disorders. Second, excessive destruction of white blood cells, such as from infections or immunological factors, leading to increased destruction of white blood cells. Third, abnormal distribution of white blood cells, due to various reasons, causes an increase in white blood cells in the marginal pool and a decrease in the circulating pool, which can also lead to leukopenia.