Mitral valve regurgitation leading to an increased pulse pressure difference is a very common phenomenon, which is related to the condition of mitral valve regurgitation itself. This is because when the left ventricle is in systole, the incomplete closure of the mitral valve causes the blood in the left ventricle to flow back into the left atrium, significantly increasing the volume of blood in the left atrium. When the ventricle is in the diastolic filling phase, a large amount of blood from the left atrium enters the left ventricle. At the same time, the left ventricle receives blood from the left atrium as well as the blood remaining from the systolic phase of the ventricle, resulting in a significant increase in the volume of blood the ventricle pumps. This leads to a notable rise in systolic pressure, thereby increasing the pulse pressure difference.