The cause of cor pulmonale

Written by Li Tao
Pulmonology
Updated on September 01, 2024
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Cor pulmonale, also known as pulmonary heart disease, refers to the increased pulmonary vascular resistance caused by pathological changes in the bronchi, lung tissue, thorax, or pulmonary vessels, leading to pulmonary arterial hypertension and subsequent structural and functional changes in the right ventricle. This condition is clinically referred to as cor pulmonale. The causes of cor pulmonale can be divided into three main categories: The first category is diseases of the bronchi and lungs, such as chronic obstructive pulmonary disease (COPD), which accounts for approximately 80%-90% of cases. Other causes include bronchial asthma, bronchiectasis, severe pulmonary tuberculosis, interstitial pneumonia, and more. The second category involves diseases related to disorders of thoracic cage movement, such as various thoracic deformities, kyphoscoliosis, spinal tuberculosis, arthritis leading to extensive pleural adhesions, and deformities caused by thoracic plastic surgery. The third category includes pulmonary vascular diseases, such as pulmonary arterial hypertension, pulmonary thromboembolism, and other conditions leading to narrowing or blockage of pulmonary arteries, all of which can progress to cor pulmonale.

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Can heart disease be inherited?

Whether heart disease is hereditary depends on the specific type of heart disease. Some heart conditions are hereditary diseases, such as hypertrophic cardiomyopathy, which is an autosomal dominant inherited disease and can be inherited. Some heart diseases are related to genetics, such as coronary heart disease and dilated cardiomyopathy. These genetically related diseases significantly increase the risk of their offspring developing these conditions, but it does not necessarily mean that they will develop the disease, as environmental factors also play a crucial role. Of course, some heart diseases are not genetic, such as most congenital heart diseases, heart valve diseases, infective endocarditis, and myocarditis, which are not related to genetics.

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Symptoms of cor pulmonale

Cor pulmonale refers to a disease characterized by increased pulmonary vascular resistance due to pathologies of the bronchi, lung tissue, chest wall, and blood vessels of the lungs, leading to pulmonary arterial hypertension and structural and functional changes in the right ventricle. The common clinical symptoms of cor pulmonale include coughing, expectoration, shortness of breath, significant palpitations, and breathing difficulties after physical activity, reduced work capacity, and exacerbation of the above symptoms during acute infection phases. Some patients may experience chest pain and hemoptysis. The second set of symptoms relates to heart and lung function, manifesting during the decompensation phase. For instance, some patients may develop respiratory failure, and experience headaches, decreased appetite, drowsiness, significant edema in the lower extremities, and further symptoms such as arrhythmias, anorexia, abdominal distension, and nausea.

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Manifestations of Cor Pulmonale

Cor pulmonale refers to a disease characterized by changes in heart structure and function due to increased pulmonary vascular resistance caused by pathological conditions of the bronchi, lungs, thoracic cage, or pulmonary vessels, leading to pulmonary arterial hypertension. This condition is collectively known as cor pulmonale. The clinical manifestations of cor pulmonale generally develop slowly. Clinically, in addition to pulmonary and pleural symptoms, there gradually appear signs of pulmonary cardiac failure and damage to other organs. Common symptoms include coughing, expectoration, palpitations, dyspnea, fatigue, decreased endurance to physical activity. In the decompensated stage, symptoms such as worsening dyspnea, headaches, insomnia, decreased appetite, and even some signs of right heart failure like palpitations, poor appetite, abdominal bloating, nausea, and swelling of the lower limbs may occur.

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Is rheumatic heart disease serious?

Rheumatic heart disease is a type of organic heart disease caused by an abnormal immune response, leading to pathological changes in the heart valves, which pose significant risks to the body. Due to valve insufficiency or stenosis, rheumatic heart disease causes changes in hemodynamics, leading to heart failure and pulmonary edema. These are severe conditions for patients and require timely treatment and correction. If effective dietary therapy is not administered, especially for pulmonary edema, it can be life-threatening.

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How long does heart disease generally hurt?

1. Chest pain caused by angina due to coronary heart disease is located in the middle to lower third of the sternum, with unclear boundaries. It is often triggered by physical activities or emotional excitement and may radiate to the throat, lower jaw, left shoulder, and inner side of the left arm. The pain lasts for a few minutes to more than ten minutes, typically between three to five minutes, and rarely exceeds half an hour. It can be relieved by rest or by taking nitroglycerin under the tongue. The nature of the pain is feelings of stuffiness, pressure, or constriction, and may also feel like a burning sensation, but is not sharp like needle pricks or cuts. 2. The location and nature of the chest pain in acute myocardial infarction are the same as with angina, but it lasts longer, is more severe, and its triggers are less evident. It can occur even while at rest, accompanied by symptoms such as sweating, nausea, vomiting, heart palpitations, and difficulty breathing. Unlike with angina, regular rest or taking nitroglycerin under the tongue does not completely alleviate the pain.