The medications commonly used for depression in clinical settings are selective serotonin reuptake inhibitors, primarily used to increase serotonin levels in the patient's brain to improve depressive symptoms. Representative drugs in clinical use include paroxetine, sertraline, fluoxetine, fluvoxamine, citalopram, and escitalopram. There are also medications that inhibit the reuptake of both serotonin and norepinephrine, such as venlafaxine and duloxetine. Additionally, there's a type of antidepressant that acts on norepinephrine and is specifically serotonergic, with mirtazapine being the main drug. These medications are considered modern antidepressants and have a relatively significant clinical efficacy. Of course, there are also traditional tricyclic and tetracyclic antidepressants, which are not recommended as first-line treatments in clinical settings due to their more adverse reactions. (Please follow a doctor's guidance regarding the use of specific medications.)