Angular cheilitis is somewhat related to patients staying up late. When patients stay up late for a long period, it can lead to the depletion of certain vitamins and nutrients in the body, causing a decrease in their resistance to illnesses. This may result in angular cheilitis or other discomfort symptoms. Therefore, it is advised that patients pay attention to developing good living habits, which are beneficial for their health. If staying up late persistently weakens the body's resistance, it might lead to various diseases. Patients are advised to cultivate good dietary habits. Frequent late nights might also lead to endocrine disorders, reduced resistance to diseases, and bacterial infections, causing other discomforts. Dietary habits should also be light, including more fresh vegetables and fruits, and an appropriate supplement of vitamins and nutrients is recommended. Thus, patients are advised to avoid staying up late as much as possible.