The first sign of breast cancer can be a lump in the breast, where lumps might be palpable in the upper outer quadrant of the breast; the second symptom might be nipple discharge or bleeding; the third symptom might be pain in the breast; the fourth symptom might involve changes in the skin of the breast, such as the skin becoming rough and possibly developing an orange peel texture; the fifth symptom might be nipple retraction and changes in the areola.