Breast cancer is somewhat related to genetics and has a certain familial predisposition. It manifests as a higher incidence rate in relatives with breast cancer, especially in closer blood relations, and daughters may develop the disease at an earlier age than their mothers. There is also a higher risk of bilateral occurrence and a tendency for other malignant tumors to develop in different parts of the body. Additionally, if a family has at least two sisters with breast cancer and their mother is not afflicted by the disease, the susceptibility of this family is about three times higher than average, commonly occurring after menopause, and usually affecting one side. Of course, the influence of human genetic factors on the development of breast cancer is multifaceted. The occurrence of breast cancer is affected not only by genetic factors but also by many other factors, which have a cumulative effect of risks. It is recommended that individuals from families with a history of breast cancer should undergo regular screening, improve their lifestyle, and avoid the accumulation of risk factors, which can also enable earlier detection and treatment of breast cancer that has already developed.