Currently, there is no consensus on the specific causes of brain gliomas. Most scholars believe they result from a combination of congenital genetic factors and acquired factors.

In the case of congenital factors, by tracing the medical history of patients with gliomas, it can be found that there is a tendency for a higher concentration of glioma cases among family members.

Acquired factors are mostly seen in severe cranial trauma, extensive gliocyte proliferation, or due to unhealthy lifestyle habits, exposure to carcinogenic chemicals, or long-term damage from highly polluted radiation, which may easily trigger the development of gliomas.