Late-stage symptoms of glioma

Written by Jiang Fang Shuai
Neurosurgery
Updated on September 02, 2024
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The continuous growth of gliomas or the occurrence of tumor stroke hemorrhages can lead to very high intracranial pressure in patients in the late stages. This results in severe headaches with persistent attacks, accompanied by nausea and vomiting. Projectile vomiting is a typical manifestation of increased intracranial pressure. Patients may experience changes in consciousness, such as drowsiness, stupor, and coma. As the condition progresses to brain herniation, patients can fall into a deep coma, with either bilateral or unilateral pupil dilation and loss of light reflex. Vital signs become unstable, ultimately leading to death due to heart and respiratory arrest caused by the brain herniation.

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Written by Chen Yu Fei
Neurosurgery
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The etiology of glioma

At present, there is no definitive conclusion regarding the specific causes of glioma. Clinically, it is generally considered the result of a combination of congenital genetic factors and acquired environmental factors. Usually, it is believed that there is a significant familial aggregation tendency in the family medical history of patients with gliomas, with a higher incidence of gliomas among family members. Additionally, acquired factors, such as severe cranial trauma followed by extensive proliferation of neuroglial cells, may induce incidents. Furthermore, severe intracranial infections, including unhealthy lifestyles, poor living environments, and the influence of radioactive materials, could potentially lead to the occurrence of gliomas.

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Is glioma a terminal illness?

Glioblastoma is not an incurable disease. Patients with glioblastoma have a type of malignant tumor that tends to grow rapidly. These tumors often adhere to surrounding brain tissue in the early stages, making complete surgical removal difficult. If any glioma cells remain after surgery, the tumor tissue will gradually grow over time. Thus, patients with glioblastoma are prone to recurrence, but it is not an incurable disease. If early detection and surgical removal can be achieved, and supplemented by radiotherapy and chemotherapy, it can maximize the therapeutic effects of the surgery, thereby effectively improving the prognosis and delaying the progression of the disease. This approach can relatively extend the patient's lifespan, and some patients may even achieve long-term survival.

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Written by Chen Yu Fei
Neurosurgery
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Is glioma malignant?

Glioblastoma is a type of malignant tumor, which generally grows at a fast pace. In the early stages of the disease, the glioma often adheres to the surrounding tissues, posing significant challenges for future complete surgical removal. At the same time, extensive cerebral edema occurs around the glioma. If prolonged, this can lead to a serious increase in intracranial pressure, manifesting as repeated headaches, dizziness, nausea, and vomiting in the patient. Over time, this condition may also lead to optic nerve atrophy, resulting in decreased vision and visual field defects. Diagnosis generally benefits from cranial CT or MRI scans, but definitive diagnosis still requires surgical removal of the tumor. A small amount of tumor tissue is typically retained for pathological biopsy.

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Written by Chen Yu Fei
Neurosurgery
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Glioma Symptoms

For patients with glioma, they often exhibit certain degrees of headache and dizziness, with headaches typically located bilaterally in the frontal or temporal regions. The nature of the pain is relatively sharp, manifesting as intermittent attacks that progressively worsen over time. Long-standing gliomas easily induce a notable increase in intracranial pressure, presenting with severe headaches, nausea, vomiting, and even a decrease in vision or visual field defects. When the glioma is located in the parietal lobe and affects important motor function areas, it can lead to unilateral or bilateral limb weakness, numbness, pain, and possibly even trigger hemiplegia.

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Can gliomas be inherited?

Gliomas have a certain hereditary proportion, but this is not an absolute concept. In clinical practice, there is no clear explanation for the pathogenic factors of gliomas, and theories are generally speculative. For instance, one factor is genetic nature, and there is also some familial clustering which supports the idea of a genetic predisposition. However, it is usually easier to identify purely genetic diseases, but gliomas often involve the inheritance of multiple genes, making it difficult to pinpoint the fundamental factors directly. Additionally, other factors include exposure to radiation and engaging in harmful work, such as producing methanol or solvents, etc. These can also cause genetic mutations leading to gliomas, so the issue is not necessarily solely genetic.