Early symptoms of neuroblastoma

Written by Chen Yu Fei
Neurosurgery
Updated on January 09, 2025
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For neuroblastoma, in the early stages of the disease, mild headaches, dizziness, nausea, and vomiting often occur, but the symptoms are relatively mild and most can be tolerated. As the disease gradually progresses and the tumor volume begins to increase, it compresses the surrounding brain tissue and cranial nerves, causing the patient to exhibit certain degrees of headache, dizziness, nausea, vomiting, and other clinical manifestations. As the tumor volume further increases and cerebral edema becomes apparent with elevated intracranial pressure, it may lead to cranial nerve dysfunction in patients. For instance, it might trigger epileptic seizures or cause patients to experience hemiplegia, aphasia, and other clinical manifestations. Once these symptoms occur, it is advisable to visit a local hospital early for treatment.

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Written by Chen Yu Fei
Neurosurgery
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Late-stage symptoms of neuroblastoma

For patients with neuroblastoma, they often experience significant symptoms such as headaches, dizziness, nausea, and vomiting. The intracranial pressure continuously rises, leading to noticeable optic atrophy, vision loss, and visual field defects. When the tumor volume further increases, it may also compress the surrounding tissues, causing apparent cranial nerve dysfunction. Moreover, in the late stages of the disease, the tumor can spread to other parts of the body via the bloodstream, forming metastases. Additionally, it is likely to disseminate through the cerebrospinal fluid.

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Written by Chen Yu Fei
Neurosurgery
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How is neuroblastoma diagnosed?

For patients with neuroblastoma, diagnosis is primarily through the symptoms, signs, detailed physical examinations, medical history inquiries, and most importantly, radiological data, which includes CT scans or MRI of the head. Definitive diagnosis requires surgical removal of the tumor. A small amount of tumor tissue is retained after excision and used for pathological examination to confirm the diagnosis. Neuroblastoma is categorized as an epithelial-like malignant tumor, indicative of a high degree of malignancy. In most cases, early in the disease, the tumor adheres to surrounding tissues, which greatly complicates complete surgical removal, and most patients have a poor prognosis.

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Written by Gao Yi Shen
Neurosurgery
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Is calcification of neuroblastoma good?

In clinical practice, although calcification is a relatively favorable phenomenon, the overall condition of neuroblastoma does not change significantly because of it. Therefore, it is still not a good sign. For neuroblastoma, whether calcification occurs or not, it remains a form of tumor. Only through early surgical treatment can the problem be fundamentally resolved, otherwise, there is a tendency for recurrence and metastasis to occur later on. Moreover, it is important to note that regardless of whether the tumor calcifies, its nature does not change. Only fundamental treatment can bring better hope, so calcification does not lead to very good outcomes.

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Written by Chen Yu Fei
Neurosurgery
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neuroblastoma cure rate

Neuroblastoma is relatively likely to be a malignant tumor, typically characterized by rapid growth of malignant tumors.In the early stages of the disease, it often adheres to surrounding tissues, making it difficult to completely remove through surgery. Even with surgical treatment, the outcomes are generally modest, and recurrence is likely to occur shortly after surgery. Once recurrence occurs, the malignancy of the tumor will continue to increase.For these patients, the prognosis is poor. It is generally recommended to undergo surgical treatment early, followed by radiotherapy and chemotherapy to potentially extend the patient's lifespan, but it is usually difficult to cure.

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Written by Chen Yu Fei
Neurosurgery
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How does neuroblastoma heal itself?

Neuroblastoma cannot completely heal by itself. Once neuroblastoma is detected, patients should be promptly taken to local hospitals for treatment, be hospitalized, and undergo skull CT or MRI scans. If necessary, enhanced MRI scans can be conducted to clarify the current location of the tumor and its relationship with surrounding tissues, and to determine the surgical plan. The tumor should be completely removed through surgery. After the surgery, a small amount of tumor tissue should be kept for pathological slides to assess the need for radiotherapy, chemotherapy, or other related treatments based on the results of the pathological examination. For some elderly and frail patients who cannot tolerate surgery, Gamma Knife treatment can also be considered.