Obesity is formed in what way?

Written by Tang Zhuo
Endocrinology
Updated on April 02, 2025
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Obesity, also known as adiposity, is a chronic metabolic disorder caused by an excessive accumulation of fat in the body or abnormal fat distribution. The exact causes of obesity are not clear, but it is generally believed to be the result of the interaction of multiple factors including environmental and genetic factors. In terms of environmental factors, there is a tendency for obesity to cluster in families; individuals with one or both parents who are obese have a significantly increased likelihood of being obese themselves. The second factor is environmental influences. Consuming more calories than are expended is the primary cause of obesity. Additionally, sedentary lifestyles, lack of physical exercise, and insufficient physical activity all contribute to reduced energy expenditure, leading to obesity. Poor dietary habits, such as eating large portions, a preference for sweets, or oily foods, also increase calorie intake and contribute to the occurrence of obesity. Furthermore, genetic mutations can also lead to obesity. Another viewpoint suggests that childhood obesity can increase the incidence of adult obesity, with people who were obese after the age of six having a more than 50% chance of being obese in adulthood.

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Written by Tang Zhuo
Endocrinology
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Causes of Obesity

Obesity, also known as adiposis, is a chronic metabolic disease caused by excessive accumulation or abnormal distribution of fat in the body. It results from the interaction of multiple factors including genetic and environmental factors that cause fat accumulation. Primary obesity, also known as simple obesity, is the most common type and is mainly caused by poor dietary habits, such as excessive food intake, particularly excessive fats, and a sedentary lifestyle. There is also secondary obesity, which is generally caused by diseases of the endocrine system. Hormonal treatments for allergic diseases and rheumatic diseases can also lead to secondary obesity.

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Written by Zhang Jun Jun
Endocrinology
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Obesity is a disease.

Obesity is related to an excessive accumulation of fat in the body, or abnormal distribution of fat, leading to weight gain. The causes include environmental factors, genetic factors, and other elements interacting to trigger this metabolic disease. Nowadays, dietary patterns have resulted in an increasing population of overweight and obese individuals. Therefore, it is crucial to understand the causes of obesity. If it is a case of simple obesity, it can be managed through diet and exercise. If it is pathological obesity, such as Cushing's syndrome, this type of obesity primarily causes abdominal obesity, thin limbs, abdominal purple streaks, and may also include increased facial acne. In such cases, medical or even surgical interventions might be necessary.

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Written by Luo Juan
Endocrinology
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Can obesity be treated?

Obesity is treatable. Generally, the treatment of obesity mainly includes several aspects: First, dietary intervention; second, increased physical activity; third, correcting bad behavioral habits; some cases may require medication and surgery. Dietary treatment mainly involves reducing calorie intake and recommending a low-sugar diet. Physical exercise generally requires three to five days of activity per week, with 30-40 minutes each day being appropriate. It also includes correcting some poor dietary habits and enhancing self-monitoring, including records of food intake and daily physical activity. Medication treatment is an option for individuals with a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher who also have obesity-related comorbidities. This treatment can be combined with exercise and dietary behavioral corrections. Furthermore, for those with a BMI of 40 or higher, or a BMI between 35-39.9 with one or more severe obesity-related complications such as hypertension, heart failure, type 2 diabetes, or sleep apnea, surgical treatment may be considered.

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Written by Tang Zhuo
Endocrinology
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The Harms of Obesity

Mild to moderate primary obesity might not present with noticeable symptoms. However, individuals with severe obesity may experience heat intolerance, reduced physical activity capability, mild shortness of breath during activities, and snoring during sleep. The likelihood of developing coronary heart disease and hypertension is significantly higher in obese individuals compared to those who are not obese. Obesity leads to reduced lung capacity and decreased pulmonary compliance, which can cause various pulmonary functional abnormalities. For instance, obese hypoventilation syndrome, clinically characterized by sleepiness, obesity, and alveolar hypoventilation, often accompanies obstructive sleep apnea. Severe cases of obesity may lead to pulmonary heart syndrome. Obese individuals often experience metabolic disorders of lipids and carbohydrates; lipid metabolism disorders can lead to hypertriglyceridemia and hypercholesterolemia, while carbohydrate metabolism disorders are marked by glucose intolerance and diabetes. Moreover, obese individuals are more prone to arthritis, gout, and osteoporosis. Sexual dysfunction is common in obese individuals, with some obese men developing gynecomastia; obese girls tend to have an earlier onset of menstruation, while adult women with obesity often experience menstrual disorders, and in severe cases, amenorrhea. The incidence of polycystic ovary syndrome is also significantly higher in obese women compared to non-obese women.

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Written by Luo Juan
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How is obesity treated?

Regarding the treatment of obesity, the cause of obesity must first be identified. For patients with simple obesity, the primary approach involves lifestyle interventions, including exercise and diet. The diet should involve a calculation of caloric intake based on activity levels, generally focusing on a low-calorie or very low-calorie intake. Additionally, it is recommended to engage in suitable aerobic exercises. Currently, there are products available such as fat enzyme inhibitors that reduce weight by inhibiting the absorption of fats in the intestines. Also, in the United States, GLP-1 agonists are available for the treatment of simple obesity. If obesity is caused by certain medical conditions, such as an endocrine disorder known as Cushing's syndrome, which can also lead to obesity, treatment should first address the primary disease, which would also resolve the obesity.