How is a pituitary tumor caused?

Written by Chen Yu Fei
Neurosurgery
Updated on March 18, 2025
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At present, there is no definitive conclusion on how pituitary tumors are formed and further developed. Clinically, it is mostly believed to be the result of a combination of congenital genetic factors and adverse environmental factors acquired later in life. For patients with pituitary tumors, they are often seen in some special familial genetic diseases. In the family medical history, a tendency for a higher accumulation of family members can be observed. Additionally, some pituitary tumor patients are also found in clear familial genetic endocrine diseases. Moreover, patients who are overworked, fatigued, under stress, and experience endocrine hormone disorders are also affected. Exposure to radioactive contamination and chemical carcinogens can also potentially lead to pituitary tumors.

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Written by Chen Yu Fei
Neurosurgery
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How long is the surgery for a pituitary tumor?

The duration of pituitary tumor surgery is influenced by many factors. For instance, the size of the pituitary tumor and whether the surgical procedure goes smoothly, as well as the presence of important blood vessels and nerves around the pituitary tumor, all affect the length of the surgery. Generally, for typical pituitary tumor patients, the surgery takes about two hours. For patients with larger pituitary tumors, the surgery may last up to three hours or even longer. The patient is given general anesthesia before the surgery and is moved to a recovery room to recuperate for a period afterward, and these times are also included in the duration of the surgery. Therefore, the specific length of the surgery is determined by these factors.

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Written by Chen Yu Fei
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Can pituitary tumors cause headaches?

For patients with pituitary tumors, headaches may occur. Most patients in the early stages often experience mild headaches located behind the eye sockets, the forehead, and on both sides of the temporal area. These headaches are generally tolerable and occur intermittently. They are mostly caused by the stimulation of the tumor or the increased pressure inside the sella. When the tumor enlarges to a certain extent and breaks upward through the diaphragm sellae, headaches are often alleviated. However, if the tumor further grows into surrounding tissues, it might compress important blood vessels and nerves, resulting in recurring pain with increasing severity.

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Written by Chen Yu Fei
Neurosurgery
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Can pituitary tumors heal on their own?

Under normal circumstances, pituitary tumors generally do not heal spontaneously. Pituitary tumors are benign tumors and although they grow slowly, they tend to continue growing. When they enlarge to a certain extent, they produce a series of symptoms and signs, such as headaches behind the eye sockets, the forehead, and both temporal sides. If the tumor breaks through the sellar diaphragm, it might also affect the optic nerve, leading to decreased vision and visual field defects. Moreover, it can severely erode the pituitary gland, causing symptoms and signs like decreased pituitary function, endocrine hormone disorders, and bringing significant suffering to the patient.

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Written by Chen Yu Fei
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The difference between pituitary tumors and pituitary adenomas

The difference between a pituitary tumor and a pituitary adenoma mainly lies in the extent of the affected tissue involved. Generally, pituitary tumors may have a broader range than pituitary adenomas, meaning that pituitary tumors include pituitary adenomas. Normally, a pituitary adenoma specifically refers to tumors occurring in the anterior lobe of the pituitary gland, as this lobe primarily consists of glandular tissue. Meanwhile, the posterior lobe of the pituitary is mainly neurohypophysis. Therefore, tumors typically referred to as pituitary adenomas occur in the anterior lobe. If a tumor is in the posterior lobe, it cannot be called a pituitary adenoma, but it still falls under the category of pituitary tumors.

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Neurosurgery
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How to check for pituitary tumors?

For the examination of pituitary tumors, it can be conducted jointly through various methods such as inquiring about the patient's medical history based on symptoms and signs, as well as conducting endocrine and radiological examinations. Currently, with the continuous advancement in modern endocrinology, the use of endocrine radiology immunodiagnostic methods allows for the direct measurement of various hormones from the pituitary and hypothalamus, and functional tests of the pituitary can be performed. This helps in understanding whether there is hyperfunction in the pituitary and target organs, and provides an effective evaluation of early diagnosis of pituitary tumors, changes before and after treatment, and treatment efficacy, which is of significant importance. Additionally, judgments can also be made jointly through various methods such as cranial CT, cranial MRI, and enhanced MRI scanning of the pituitary gland.