Is a pituitary tumor serious?

Written by Chen Yu Fei
Neurosurgery
Updated on September 23, 2024
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Pituitary tumors are mostly benign. The tumors grow slowly, but due to their special location adjacent to the pituitary gland, when the size of the pituitary tumor increases to a certain extent, it will inevitably affect the pituitary, impairing its function and leading to pituitary dysfunction. This dysfunction manifests as endocrine hormonal imbalances, resulting in a series of symptoms and signs. Therefore, it is usually recommended to treat pituitary tumors surgically. Clinically, it is generally advised to choose the transnasal transsphenoidal approach for complete resection of the pituitary tumor.

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Written by Chen Yu Fei
Neurosurgery
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Can pituitary tumors cause headaches?

For patients with pituitary tumors, headaches may occur. Most patients in the early stages often experience mild headaches located behind the eye sockets, the forehead, and on both sides of the temporal area. These headaches are generally tolerable and occur intermittently. They are mostly caused by the stimulation of the tumor or the increased pressure inside the sella. When the tumor enlarges to a certain extent and breaks upward through the diaphragm sellae, headaches are often alleviated. However, if the tumor further grows into surrounding tissues, it might compress important blood vessels and nerves, resulting in recurring pain with increasing severity.

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Can pituitary tumors be cured?

Currently, for the treatment of pituitary tumors, it is generally recommended in clinical practice to opt for a complete resection via a transnasal-transsphenoidal approach. Most patients can achieve good therapeutic outcomes through surgery. The main goals of surgically treating pituitary tumors are to remove the tumor, decompress the visual pathways, and help restore and maintain the function of the pituitary and other neurological functions. Most patients can achieve good therapeutic results after treatment. Additionally, after receiving treatment, patients' original symptoms gradually alleviate or even disappear, and no longer worsen. Therefore, from this perspective, it is recommended that all symptomatic pituitary tumor patients should timely seek medical consultation at local hospitals and receive early treatment.

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Written by Chen Yu Fei
Neurosurgery
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How is a pituitary tumor caused?

At present, there is no definitive conclusion on how pituitary tumors are formed and further developed. Clinically, it is mostly believed to be the result of a combination of congenital genetic factors and adverse environmental factors acquired later in life. For patients with pituitary tumors, they are often seen in some special familial genetic diseases. In the family medical history, a tendency for a higher accumulation of family members can be observed. Additionally, some pituitary tumor patients are also found in clear familial genetic endocrine diseases. Moreover, patients who are overworked, fatigued, under stress, and experience endocrine hormone disorders are also affected. Exposure to radioactive contamination and chemical carcinogens can also potentially lead to pituitary tumors.

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Postoperative complications of pituitary tumor surgery

For patients with pituitary tumors, a range of complications, sequelae, or concomitant ailments can easily occur after surgery. For instance, postoperative sellar hematoma may occur, and some patients may even experience the rupture of a pseudoaneurysm. Additionally, some patients may repeatedly suffer from headaches, dizziness, nausea, vomiting, and weakness in the limbs after surgery, along with significant memory decline, reduced cognitive function—including calculating ability, and orientation in time, space, and person—gradually diminishing. These are considered postoperative sequelae of pituitary tumor surgery.

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Written by Chen Yu Fei
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Pituitary tumor examination items

For patients with pituitary tumors, it is first recommended to perform a cranial CT or MRI examination, and if necessary, a cranial MRI with contrast and a pituitary MRI with contrast can be done to help determine the specific location, size, and relationship of the pituitary tumor with surrounding important blood vessels and nerves. Additionally, blood tests are needed to examine the levels of endocrine hormones in the body, including cortisol, growth hormone, prolactin, thyroid hormones, and other related hormone levels. Furthermore, further examinations of the patient's cardiopulmonary function, such as electrocardiograms, echocardiograms, and chest CT scans, are also required.