Is Hashimoto's thyroiditis hereditary?

Written by Chen Xie
Endocrinology
Updated on September 12, 2024
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Hashimoto's thyroiditis is an autoimmune thyroid disease and is not hereditary. However, it tends to cluster in families, meaning if one's parents have a history of Hashimoto's thyroiditis, their offspring have a relatively higher risk of developing the disease. However, this is not absolute heredity; it simply indicates a familial clustering tendency. Treatment for Hashimoto's thyroiditis is relatively effective. If hypothyroidism occurs, one only needs to take lifelong replacement therapy with levothyroxine to maintain thyroid function within the normal range, which has minimal impact on the body. Therefore, there is no need for excessive worry.

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Written by Li Hui Zhi
Endocrinology
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Hashimoto's thyroiditis is an autoimmune disorder that attacks the thyroid gland, leading to hypothyroidism.

Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, is an autoimmune disease. Some patients with Hashimoto's thyroiditis have normal thyroid function and generally do not require treatment, but it is recommended to regularly review thyroid function and have thyroid ultrasonography. Some patients with Hashimoto’s thyroiditis may also suffer from hypothyroidism, which can manifest clinically as fatigue, constipation, and edema. If these symptoms are present, it is advisable to visit an endocrinology specialist promptly, complete thyroid function tests, and use thyroid hormone supplements under the guidance of a doctor.

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Written by Tang Zhuo
Endocrinology
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What to do with Hashimoto's thyroiditis?

Hashimoto's thyroiditis is the most common clinical type of thyroiditis, with over 90% occurring in females. It is also the major cause of primary hypothyroidism. The onset of Hashimoto's thyroiditis is insidious and progresses slowly. Early clinical manifestations are often atypical. Therefore, the treatment of Hashimoto's thyroiditis should be tailored to different circumstances. If a patient with Hashimoto's thyroiditis has normal thyroid function, then no special treatment is needed, only regular follow-up is required. If the patient develops hypothyroidism, thyroid hormone replacement therapy should be administered using either thyroxine tablets or levothyroxine tablets until the maintenance dose is reached, to improve clinical symptoms and normalize thyroid function. Another category includes patients with Hashimoto's hyperthyroidism, who generally do not require treatment as they may go through phases of hyperthyroidism, normal thyroid function, and hypothyroidism. Transient hyperthyroidism can be managed symptomatically with β-blockers. For cases highly suspected of concurrent Hashimoto's thyroiditis with thyroid cancer or lymphoma, surgical treatment can be considered.

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Written by Chen Xie
Endocrinology
1min 8sec home-news-image

Hashimoto's thyroiditis diagnostic indicators

Hashimoto's thyroiditis is a type of autoimmune thyroiditis, which can present in various phases regarding thyroid function, manifesting as hyperthyroidism, hypothyroidism, or normal thyroid function. Therefore, for patients with Hashimoto's thyroiditis, it is necessary to check thyroid function to understand its status. Since Hashimoto's thyroiditis is an autoimmune thyroiditis, the thyroid peroxidase antibodies and thyroglobulin antibodies are generally elevated. Additionally, it is necessary to perform thyroid ultrasound to assess the thyroid's condition. For some difficult-to-distinguish patients, a further examination such as a 131I uptake test can be conducted, where the uptake rate in Hashimoto's thyroiditis is reduced. Even further, a fine needle aspiration biopsy of the thyroid can be performed, where we can observe significant lymphocyte infiltration.

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Written by Chen Xie
Endocrinology
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Can Hashimoto's thyroiditis be cured?

Hashimoto's thyroiditis is an autoimmune thyroiditis where the body itself has autoantibodies that lead to the destruction of thyroid follicular cells, resulting in the failure of thyroid cells. Therefore, Hashimoto's thyroiditis can manifest as hyperthyroidism, euthyroidism, and hypothyroidism. Ultimately, Hashimoto's thyroiditis may develop into hypothyroidism. Hypothyroidism is proliferative and generally cannot be completely cured, but clinical remission can be achieved through oral administration of levothyroxine. However, Hashimoto's thyroiditis cannot be completely cured and requires lifelong replacement therapy.

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Written by Chen Xie
Endocrinology
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Does Hashimoto's thyroiditis require medication?

Hashimoto's thyroiditis refers to the destruction of thyroid tissue by autoimmune cells. Therefore, during the course of the disease, three states of thyroid function can be manifested: hyperthyroidism, euthyroid state, and hypothyroidism. When the patient presents with hyperthyroidism, it is possible to treat with anti-thyroid drugs, but the dosage of the anti-thyroid drugs should be reduced. When thyroid function is normal, no special treatment is needed, and regular thyroid function testing is sufficient. When there is concurrent hypothyroidism, thyroid hormone replacement therapy is required to achieve clinical healing.