Gallbladder cancer skin itching area

Written by Liu Wu Cai
Hepatobiliary Surgery
Updated on February 22, 2025
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Patients with gallbladder cancer may develop obstructive jaundice as the tumor size increases, which can manifest as yellowing of the skin and mucous membranes, dark urine, and pale stools. Patients may also experience itching and discomfort. For these patients, the treatment effectiveness is generally poor, and gallbladder cancer is a type of malignancy that tends to metastasize and has a very poor prognosis. Once symptoms are prominent, treatment becomes relatively difficult and less effective. It is advisable for gallbladder cancer patients to undergo surgical resection as early as possible to improve their prognosis. However, the onset of gallbladder cancer is often insidious and frequently overlooked.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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Can gallbladder cancer be detected through blood tests?

Blood tests generally cannot detect gallbladder cancer because there are no specific markers in the blood tests for gallbladder cancer. Although some tumor markers may be significantly elevated, they are not specific. Therefore, diagnosis of gallbladder cancer can be refined through abdominal CT, color ultrasound, and if necessary, puncture tissue for pathological examination to confirm the nature. Once diagnosed with gallbladder cancer, surgery should be performed as soon as possible because gallbladder cancer is a highly malignant, rapidly developing, and poor prognosis malignancy. It is important to pay attention to it and handle it promptly to improve the prognosis and potentially extend the patient’s life.

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Written by Shen Jiang Chao
Radiology
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Gallbladder cancer ultrasonographic appearance

The appearance of gallbladder cancer on color ultrasound depends on the morphology of the cancer, which is mainly divided into five types: small nodular, thick-wall, fragmented, calculous, and mixed type. The small nodular type mainly features a polypoid elevation with a wide base, about 1-1.2 cm in size, and has isoechoic characteristics. The fragmented type is characterized by a wider base and irregular borders, presenting as hypoechoic or isoechoic masses. The calculous type shows an enlarged gallbladder, possibly containing hypoechoic and uneven solid masses that may fill the entire gallbladder. The thick-wall type primarily involves localized or diffuse thickening of the wall. The mixed type is a combination of papillary fragmented type and thick-wall type presence.

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Written by Shen Jiang Chao
Radiology
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Can gallbladder cancer be detected by ultrasound?

Gallbladder cancer can also be detected by ultrasound, which is the preferred imaging method for diagnosing hepatobiliary diseases. Ultrasound can detect space-occupying lesions in hepatobiliary diseases early on. It is sensitive enough to detect lesions as small as one centimeter, or even a few millimeters. In the case of space-occupying lesions of the gallbladder, particularly gallbladder cancer, there are no particularly obvious signals on ultrasound. Ultrasound of the gallbladder is merely used as a screening tool, not as a definitive diagnostic method. If gallbladder cancer is suspected, further investigations such as MRI or enhanced CT are generally required, but the final diagnosis still relies on pathology.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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Difference between early-stage and mid-stage gallbladder cancer

For gallbladder cancer, its staging is mainly based on the size of the tumor and whether there are metastases to other parts of the body, including lymph node metastases. In early-stage gallbladder cancer patients, the tumor is generally small and there are no metastases to other parts of the body. At this stage, patients typically do not show specific symptoms. Additionally, for patients with mid-stage gallbladder cancer, they may experience discomfort or dull pain in the upper right abdomen, and may also experience weight loss, possibly even developing cachexia. Therefore, gallbladder cancer patients can undergo surgical removal and a pathological examination can provide a better assessment of the pathological stage, leading to a better treatment plan.

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Written by Li Hu Chen
Imaging Center
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Can cholecystitis be detected by color ultrasound?

If there is gallbladder cancer, usually an ultrasonography of the liver and gallbladder or the upper abdomen can detect it. Conditions such as gallbladder cancer or liver cancer are often initially discovered and diagnosed through ultrasound. Of course, the final confirmation of diagnosis is usually achieved through pathological examination after surgery. However, in terms of initial diagnosis, it is very common to identify these conditions through ultrasound. Gallbladder cancer typically presents certain characteristic changes, such as obvious thickening of the gallbladder wall, extensive thickening including sclerosis, and significant soft tissue mass growth extending to and adhering to the liver, which are strong indicators of gallbladder cancer. Additionally, a large polyp may be seen inside the gallbladder, and surgical removal at this stage may diagnose early gallbladder cancer.