Can gallbladder cancer be detected by cancer embryonic antigen test?

Written by Liu Wu Cai
Hepatobiliary Surgery
Updated on December 16, 2024
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The use of cancer embryo antigen in patients with gallbladder cancer has certain reference value, but it is not absolute.

Patients with gallbladder cancer typically show a significant increase in embryonic antigen. Gallbladder cancer is difficult to diagnose early as it generally does not show specific symptoms. Some patients may experience mild discomfort in the upper right abdomen, but this is often overlooked or misdiagnosed as other diseases, such as chronic gastritis.

Therefore, once diagnosed with gallbladder cancer, it is usually already at a middle to late stage. Although the cancer embryo antigen in tumor marker tests of gallbladder cancer patients can be elevated, this is not absolute. Therefore, when discomfort in the upper right abdomen occurs, further comprehensive examinations like color ultrasound, CT, and other related tests are necessary to differentiate it.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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Difference between early-stage and mid-stage gallbladder cancer

For gallbladder cancer, its staging is mainly based on the size of the tumor and whether there are metastases to other parts of the body, including lymph node metastases. In early-stage gallbladder cancer patients, the tumor is generally small and there are no metastases to other parts of the body. At this stage, patients typically do not show specific symptoms. Additionally, for patients with mid-stage gallbladder cancer, they may experience discomfort or dull pain in the upper right abdomen, and may also experience weight loss, possibly even developing cachexia. Therefore, gallbladder cancer patients can undergo surgical removal and a pathological examination can provide a better assessment of the pathological stage, leading to a better treatment plan.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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What foods to eat for late-stage gallbladder cancer?

Patients with advanced liver cancer will experience metastasis to other parts of the body, presenting corresponding clinical symptoms that affect the quality of life. Furthermore, patients with advanced liver cancer often exhibit significant weight loss and cachexia, commonly accompanied by hypoalbuminemia. Therefore, for patients with advanced gallbladder cancer, it is advisable to include a diet rich in high-protein foods, which can help replenish the proteins needed by the body, such as albumin, and improve the patient's immunity. It is beneficial to eat fresh vegetables, fruits, as well as lean meats, eggs, and fish, to address these symptoms appropriately. At the same time, for patients with advanced gallbladder cancer, it is important to avoid spicy and irritating foods, as well as foods that are difficult to digest, because these can increase the burden on the gallbladder, exacerbating the condition and impeding treatment. Hence, this should be given careful consideration.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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Will CA199 also be high with gallbladder cancer?

Gallbladder cancer CA199 levels are likely to be elevated. In the case of gallbladder cancer, it is a common malignant tumor of the digestive system. When tumor markers are evaluated, an increase in CA199 can be observed. For patients with gallbladder cancer, it is advisable to undergo surgical removal as early as possible to improve prognosis. Generally, early-stage gallbladder cancer patients do not show specific symptoms, and some may only experience upper abdominal bloating and discomfort, which is often overlooked. Therefore, once diagnosed with gallbladder cancer, it is usually at a mid-to-late stage. At this point, treatment can only be symptomatic and not curative, and the treatment outcome is relatively poor. However, active management is still necessary to prevent the worsening of the condition.

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Written by Shen Jiang Chao
Radiology
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MRI manifestations of gallbladder cancer

The manifestations of gallbladder cancer on MRI primarily include significant thickening of the gallbladder wall or a mass within the gallbladder. Generally, it appears as low signal on T1-weighted images and high signal on T2-weighted images. After enhancement, the lesion shows obvious enhancement. If the lesion is large, necrosis may occur internally. Since the gallbladder is close to the liver, if abnormal signals are found in the liver, intrahepatic metastasis should be considered, which further confirms the possibility of gallbladder cancer. Additionally, gallbladder cancer can also invade the nearby bile ducts, causing dilation of the bile ducts, as well as local or distant lymph node metastasis.

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Radiology
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Gallbladder cancer ultrasonographic appearance

The appearance of gallbladder cancer on color ultrasound depends on the morphology of the cancer, which is mainly divided into five types: small nodular, thick-wall, fragmented, calculous, and mixed type. The small nodular type mainly features a polypoid elevation with a wide base, about 1-1.2 cm in size, and has isoechoic characteristics. The fragmented type is characterized by a wider base and irregular borders, presenting as hypoechoic or isoechoic masses. The calculous type shows an enlarged gallbladder, possibly containing hypoechoic and uneven solid masses that may fill the entire gallbladder. The thick-wall type primarily involves localized or diffuse thickening of the wall. The mixed type is a combination of papillary fragmented type and thick-wall type presence.