The Difference between Nasopharyngitis and Nasopharyngeal Carcinoma

Written by Zhang Jun
Otolaryngology
Updated on February 24, 2025
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The differences between nasopharyngitis and nasopharyngeal carcinoma are very clear. Firstly, nasopharyngitis is an acute inflammatory irritation, while the cause of nasopharyngeal carcinoma is currently unknown, generally associated directly with EB virus infection. Secondly, their clinical manifestations are different. Patients with nasopharyngitis may experience dryness and pain in the nasopharyngeal area, and yellow secretions may occur when clearing the throat in the morning. In contrast, nasopharyngeal carcinoma typically presents as a painless mass. During examination with a nasopharyngoscope, the surface of nasopharyngitis is congested and swollen, whereas in nasopharyngeal carcinoma, cauliflower-like neoplasms or ulcers can be found at the top of the nasopharynx or near the pharyngeal recess. A local pathological examination can reveal symptoms and clarify the diagnosis. In terms of treatment, nasopharyngitis requires symptomatic anti-inflammatory treatment, while nasopharyngeal carcinoma requires local radiotherapy or chemotherapy.

Other Voices

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How to check for nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a malignant tumor in the nasal area, clinically mainly squamous cell carcinoma. The incidence of nasopharyngeal carcinoma is relatively high in southern regions of our country. Clinically, the primary treatment is radiotherapy. For diagnosis, the first general step involves using an electronic nasopharyngoscope to examine the nasopharyngeal area for suspicious conditions. Further imaging studies can also be conducted, such as CT scans and MRI scans of the nasopharyngeal area. Through these examinations, if a neoplasm in the nasal area is essentially identified and suspected to be nasopharyngeal carcinoma, an endoscopic examination is conducted where forceps are used to clip tissue for a pathological biopsy. The pathological biopsy determines whether it is definitively nasopharyngeal carcinoma and identifies the type of cancer cells, thus guiding clinical treatment.

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What causes nasopharyngeal carcinoma?

The specific cause of nasopharyngeal carcinoma, a type of malignant tumor, is currently unclear, but it is considered to be related to some high-risk factors that may lead to the occurrence of nasopharyngeal cancer. Firstly, there are cases of EB virus infections in the nasopharyngeal area. The long-term stimulation of the nasopharyngeal mucosa by this virus leads to hyperplasia of the mucosa, which can become malignant and eventually form nasopharyngeal cancer. Additionally, some clinical studies suggest that the occurrence of nasopharyngeal carcinoma is related to genetic factors, indicating a genetic predisposition to nasopharyngeal carcinoma, which leads to its development. Furthermore, some considerations involve external carcinogenic factors affecting the nasopharyngeal area, such as long-term smoking or environmental air pollution, which can also lead to a high incidence of nasopharyngeal cancer.

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Do people with nasopharyngeal carcinoma lose weight?

Some patients with nasopharyngeal carcinoma may experience weight loss, but individual differences exist. This is somewhat related to the condition itself as well as to the individual's resistance and their baseline physical fitness. If the condition is detected early and the clinical symptoms are not particularly obvious, most patients will not show significant weight loss, and many people may not have noticeable symptoms. If the condition is severe, and diet and nutrition are not properly managed in a timely manner, patients may experience weight loss, especially in advanced stages of the illness. This can result in a cachectic-like state, which poses greater challenges for treatment. It is necessary to seek medical attention promptly, assess the physical condition, and consider the need for radiotherapy and chemotherapy.

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Nasopharyngeal carcinoma clinical manifestations

Nasopharyngeal carcinoma is the most common malignant tumor in the nasopharyngeal area, and clinically, it is primarily squamous cell carcinoma. The incidence of nasopharyngeal carcinoma is particularly high in the southern regions of China, especially in Guangdong. Initially, nasopharyngeal carcinoma manifests locally as a tumorous mass in the nasopharyngeal area, often with ulceration on the surface. This can lead to the presence of blood in nasal mucus, known as bloody nasal discharge. As the disease progresses, there can be swelling of the cervical lymph nodes, primarily involving the upper deep cervical lymph nodes, with about 60% of patients experiencing this type of lymph node enlargement. As the tumor enlarges, it may block the nasal passage, leading to persistent nasal congestion. The tumor's pressure on the Eustachian tube can cause symptoms of secretory otitis media. Furthermore, damage to the skull base by the tumor can lead to severe headaches. As a malignant tumor, the cancer can cause systemic symptoms such as malnutrition and cachexia. In advanced stages, metastatic symptoms may appear, such as bone and liver metastases, affecting these vital organs.

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symptoms of nasopharyngeal carcinoma with liver metastasis

Patients with nasopharyngeal carcinoma who experience liver metastasis present with multiple symptoms, the more common ones being abdominal pain and possible facial jaundice. Some patients may also experience poor appetite and weight loss. The specific symptoms vary from individual to individual. When such conditions occur, it is important to seek medical attention at an oncology department promptly and undergo a comprehensive body examination to determine the extent of the condition, which will facilitate targeted treatment. Current common treatment methods include interventional therapies and chemotherapy. However, overall, the treatment of nasopharyngeal carcinoma with liver metastasis is very challenging, and the treatment outcomes are generally not very favorable.