Distinction between Nasopharyngitis and Nasopharyngeal Carcinoma

Written by Deng Bang Yu
Otolaryngology
Updated on September 20, 2024
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Nasopharyngitis and nasopharyngeal carcinoma have fundamental differences. Nasopharyngitis is an inflammatory disease, while nasopharyngeal carcinoma is a malignant tumor disease. Clinically, nasopharyngitis mainly presents with increased secretions in the nasopharyngeal area, sometimes with a slight amount of bloody secretions, but this is extremely rare. On the other hand, nasopharyngeal carcinoma primarily shows symptoms such as the proliferation of malignant tumor tissues in the nasopharynx, enlargement of the lymph nodes in the neck, headaches, and ear stuffiness. In terms of treatment, nasopharyngitis is primarily treated with medications, such as traditional Chinese medicines, nasal sprays, and nasal corticosteroids; whereas nasopharyngeal carcinoma is primarily treated with radiotherapy combined with chemotherapy, which is currently the common sandwich therapy. Overall, there are fundamental differences between the two.

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Characteristics of headaches caused by nasopharyngeal carcinoma

Nasopharyngeal carcinoma is a relatively common otorhinolaryngological disease with various clinical symptoms. The more common symptoms include nasal congestion, runny nose, and bloody nasal discharge. Some patients may experience headaches, which could potentially be due to intracranial metastasis of the nasopharyngeal carcinoma or nerve invasion, causing neuropathic pain. The specific characteristics of the headache mainly manifest as persistent and severe pain. Although pain relief medications can temporarily alleviate the symptoms, the relief usually does not last long. After the effects of the medication wear off, the pain may recur. Moreover, this condition is generally challenging to treat, and treatment outcomes may not be ideal.

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Does nasopharyngeal carcinoma require surgery?

Nasopharyngeal carcinoma generally does not consider surgery. For most patients with nasal cancer, radiotherapy is the first choice, and depending on the different stages, it may be necessary to consider concurrent or adjuvant chemotherapy. The overall treatment plan primarily focuses on curative radiotherapy, and it also requires regular follow-ups to monitor recovery. If radiotherapy and chemotherapy fail or there is a recurrence, surgery may need to be considered in these cases, but the surgery is relatively difficult, and a detailed analysis of the patient's specific situation is required. Only a very small number of patients would be indicated for surgery.

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What is nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a relatively common malignant tumor in the nasopharyngeal area, and the main pathological type is predominantly squamous carcinoma, most of which are poorly differentiated squamous carcinomas, constituting the most common malignant tumor in the nasopharyngeal area. Currently, the primary treatment option is radiotherapy, which is the most important; some patients may need to consider concurrent or adjuvant chemotherapy. If drug and radiotherapy treatments are ineffective, or if there is cervical lymph node metastasis, and for some patients where chemoradiotherapy fails with residual lesions, surgery may be considered. However, currently, the surgical treatment approach is generally not very mature and is somewhat controversial, thus it requires treatment at major hospitals.

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Written by Deng Bang Yu
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How is nasopharyngeal carcinoma diagnosed?

Nasopharyngeal carcinoma is a malignant, occupying lesion that occurs in the nasopharyngeal area, and clinically it is mainly squamous cell carcinoma. Relatively speaking, although this tumor is malignant, its degree of malignancy is relatively low, especially when compared to liver cancer, lung cancer, and other malignant tumors. The definitive diagnosis of any tumor primarily relies on histopathological diagnosis, which means that pathological examination is the gold standard. In the case of nasopharyngeal carcinoma, we can make a pathological examination by using nasopharyngeal biopsy tissue with forceps under nasendoscopy. If cancer cells are found, then it is essentially confirmed. Of course, other examination methods, such as CT and MRI, are also helpful in diagnosing nasopharyngeal carcinoma and determining whether there are any metastases.

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Written by Deng Bang Yu
Otolaryngology
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What are the symptoms of late-stage nasopharyngeal carcinoma?

Nasopharyngeal cancer is a common malignancy in otolaryngology, primarily located in the nasopharyngeal area. In advanced stages, nasopharyngeal cancer manifests symptoms in two main aspects. One involves symptoms directly caused by the cancer or its metastasis, typically presenting as increased nasal masses, enlarged cervical lymph nodes, severe headaches, decreased hearing, and bleeding in the nasal area due to tumor cells or tissue eroding the internal carotid artery. Additionally, there is a foul smell from the nasopharyngeal area. The second aspect relates to systemic symptoms due to the growth of nasopharyngeal cancer, leading to poor overall nutritional status and cachexia, characterized by extreme emaciation. There is also the potential for distant metastasis of the tumor cells, presenting symptoms in the corresponding areas.